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Clin Chem:心肌肌钙蛋白时间动态变化与普通人群的心血管事件风险

2019-07-20 gladiator MedSci原创

在一般人群中,心肌肌钙蛋白与心血管风险相关,但心肌肌钙蛋白I的时间变化是否可提供独立的预后信息仍不确定。在此,研究人员使用一个以社区为基础的大型队列,跟踪调查了心脏肌钙蛋白的时间变化与心血管事件之间的关系。 测量与高灵敏度测定心肌肌钙蛋白I (hs-cTnI) 4805年参与者参加第二(HUNT2,1995 - 97)和第三次(HUNT2006 - 2008)的前瞻性Nord-Trøndel

在一般人群中,心肌肌钙蛋白与心血管风险相关,但心肌肌钙蛋白I的时间变化是否可提供独立的预后信息仍不确定。在此,研究人员使用一个以社区为基础的大型队列,跟踪调查了心脏肌钙蛋白的时间变化与心血管事件之间的关系。

测量与高灵敏度测定心肌肌钙蛋白I (hs-cTnI) 4805年参与者参加第二(HUNT2,1995 - 97)和第三次(HUNT2006 - 2008)的前瞻性Nord-Trøndelag卫生(HUNT)研究。研究团队构建了从HUNT 2HUNT 3 hs-cTnI的相对变化和绝对变化的统计模型。产生心血管死亡或心肌梗死或心力衰竭首次入院的复合终点。

hs-cTnI相对下降的患者多为年轻女性,血压和体重指数较低。hs-cTnI相对增高者多为老年男性,收缩压较高。hs-cTnI相对增加的校正危险率(HR)1.68 (95% CI, 1.16-2.42),相对减少的校正危险率为1.19 (95% CI, 0.84-1.68)hs-cTnI的绝对升高与hs-cTnI的相对升高具有相似的预后特性。最新的hs-cTnI的测量结果在识别和重新分类模型上优于变化变量。

hs-cTnI的相对和绝对升高均与心血管风险独立相关。为了改进风险预测模型,临床实践中应优先采用最新的hs-cTnI测量方法。

原始出处:

Magnus N. Lyngbakken, Helge Røsjø,Temporal Changes in Cardiac Troponin I Are Associated with Risk of Cardiovascular Events in the General Population: The Nord-Trøndelag Health Study

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    2019-07-21 逆鳞⊙ω⊙

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