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Proteomes:尿液比较蛋白组学分析阐释了急性期反应信号和LXR/RXR激活通路在前列腺癌中下调

2018-01-18 AlexYang MedSci原创

利用非侵入型诊断标记来检测前列腺癌(PCa)仍旧是一种挑战。最近,有研究人员对尿蛋白进行了鉴定,旨在鉴定出能够在早期阶段对PCa具有足够敏感性和特异性检测的尿蛋白。研究人员对患有PCa、良性前列腺增生、膀胱癌和肾癌的病人,结合生物信息学分析,进行了尿液的比较蛋白组学分析。研究发现,在2-D DIGE/MS和无标签LC-MS/MS实验中,分别有20个和85个蛋白在丰度上具有统计学显著差异。信息学分析

利用非侵入型诊断标记来检测前列腺癌(PCa)仍旧是一种挑战。最近,有研究人员对尿蛋白进行了鉴定,旨在鉴定出能够在早期阶段对PCa具有足够敏感性和特异性检测的尿蛋白。研究人员对患有PCa、良性前列腺增生、膀胱癌和肾癌的病人,结合生物信息学分析,进行了尿液的比较蛋白组学分析。

研究发现,在2-D DIGE/MS和无标签LC-MS/MS实验中,分别有20个和85个蛋白在丰度上具有统计学显著差异。信息学分析表明了激活、结合和一部分免疫细胞移动在PCa中是受影响最高的细胞功能,还包括了急性期反应信号和LXR/RXR激活通路的下调。其中,最具有希望的生物标记有35个,在PCa中,它们与很多组相比均有改变。有一半的标记定位在正常的或者PCa组织中。有20个蛋白(CD14, AHSG, ENO1, ANXA1, CLU, COL6A1, C3, FGA, FGG, HPX, PTGDS, S100A9, LMAN2, ITIH4, ACTA2, GRN, HBB, PEBP1, CTSB, SPP1)为致癌性的、肿瘤抑制子和多功能蛋白,并且参与PCa,然而,9个蛋白(AZU1, IGHG1, RNASE2, PZP, REG1A, AMY1A, AMY2A, ACTG2, COL18A1)与不同的癌症相关,但是与PCa并没有鉴定到相关性,这也许代表着新的发现。

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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Thu Jan 18 21:25:08 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279799, encodeId=1fbe2e9799a6, content=好文章学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Jan 18 20:41:03 CST 2018, time=2018-01-18, status=1, ipAttribution=)]
    2018-01-21 海之蓝

    学习

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Thu Jan 18 21:25:08 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279799, encodeId=1fbe2e9799a6, content=好文章学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Jan 18 20:41:03 CST 2018, time=2018-01-18, status=1, ipAttribution=)]
  6. 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    2018-01-20 longqijun254
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style='color:#2F92EE;'>#MES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11574, encryptionId=0c0b115e4cf, topicName=MES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=874617863969, createdName=longqijun254, createdTime=Sat Jan 20 11:03:00 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601964, encodeId=0d7f160196441, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Sat Jan 20 11:03:00 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279831, encodeId=31d72e983198, content=利用非侵入型诊断标记来检测前列腺癌(PCa)仍旧是一种挑战.最近.有研究人员对尿蛋白进行了鉴定.旨在鉴定出能够在早期阶段对PCa具有足够敏感性和特异性检测的尿蛋白, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Jan 18 22:45:39 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279815, encodeId=73302e98154b, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Thu Jan 18 21:25:08 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279799, encodeId=1fbe2e9799a6, content=好文章学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Jan 18 20:41:03 CST 2018, time=2018-01-18, status=1, ipAttribution=)]
    2018-01-20 sunylz
  8. 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    2018-01-18 有备才能无患

    利用非侵入型诊断标记来检测前列腺癌(PCa)仍旧是一种挑战.最近.有研究人员对尿蛋白进行了鉴定.旨在鉴定出能够在早期阶段对PCa具有足够敏感性和特异性检测的尿蛋白

    0

  9. 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style='color:#2F92EE;'>#MES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11574, encryptionId=0c0b115e4cf, topicName=MES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=874617863969, createdName=longqijun254, createdTime=Sat Jan 20 11:03:00 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601964, encodeId=0d7f160196441, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Sat Jan 20 11:03:00 CST 2018, time=2018-01-20, status=1, ipAttribution=), 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Thu Jan 18 21:25:08 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279799, encodeId=1fbe2e9799a6, content=好文章学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Jan 18 20:41:03 CST 2018, time=2018-01-18, status=1, ipAttribution=)]
    2018-01-18 戒馋,懒,贪

    谢谢分享学习了

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=279831, encodeId=31d72e983198, content=利用非侵入型诊断标记来检测前列腺癌(PCa)仍旧是一种挑战.最近.有研究人员对尿蛋白进行了鉴定.旨在鉴定出能够在早期阶段对PCa具有足够敏感性和特异性检测的尿蛋白, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Jan 18 22:45:39 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279815, encodeId=73302e98154b, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Thu Jan 18 21:25:08 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279799, encodeId=1fbe2e9799a6, content=好文章学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Jan 18 20:41:03 CST 2018, time=2018-01-18, status=1, ipAttribution=)]
    2018-01-18 1e0f8808m18(暂无匿称)

    好文章学习了.

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