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JAMA Intern Med:对于健康成人,热量限制(CR)到底有没有坏处?

2016-05-07 MedSci MedSci原创

热量限制(CR)能够增加许多物种的寿命,并降低慢性疾病的危险因素。在人类中,CR可以延长健康寿命,但CR潜在负面影响也一直令人担忧。该研究的目的是探究CR对健康非肥胖成人情绪,生活质量(QOL),睡眠质量,和性功能的影响。来自美国的研究人员进行了一项多站点随机临床试验(减少能量摄入长期影响的综合评估2期研究[CALERIE 2]),该研究在3个学术研究机构进行。220名成年男性和女性,BMI为22

热量限制(CR)能够增加许多物种的寿命,并降低慢性疾病的危险因素。在人类中,CR可以延长健康寿命,但CR潜在负面影响也一直令人担忧。

该研究的目的是探究CR对健康非肥胖成人情绪,生活质量(QOL),睡眠质量,和性功能的影响。

来自美国的研究人员进行了一项多站点随机临床试验(减少能量摄入长期影响的综合评估2期研究[CALERIE 2]),该研究在3个学术研究机构进行。220名成年男性和女性,BMI为22.0至28.0,被随机以2:1的比例分配至2年的25%CR或自由饮食(AL)对照组。在基线,12个月和24个月时收集数据,采用意向性治疗进行分析。该研究在2007年1月22日至2012年3月6日期间进行,数据分析在2012年7月18日至2015年10月27日期间进行。

主要检测指标是情绪(Beck抑郁量表-II[BDI-II],得分范围0-63,评分越高表明情绪越糟糕,以及情绪状态[POMS],总情绪障碍分数范围-32至200,分数越高表示情绪状态越差),QOL(RAND36项短表,得分范围为0-100,分数越高反映较好的生活质量,以及知觉压力量表,评分范围0-40,分数越高表明有更高水平的压力),睡眠(匹兹堡睡眠质量指数[PSQI],得分范围0-21,分数越高,反映了糟糕的睡眠质量),以及性功能(Derogatis访谈性功能自我报告,总分范围24-188,分数越高表明更好的性功能)。

该研究共有218名参与者(152名女性[69.7%];平均[SD]年龄,37.9(7.2)岁;平均[SD] BMI,25.1 [1.6])被列入分析。在24个月时,CR和AL组体重平均(SE)下降了7.6(0.3)kg和0.4(0.5)kg(P <0.001)。在24个月时与AL组相比,CR组有显著的情绪改善(BDI-II:组间差异[BGD] -0.76; 95%CI,-1.41至-0.11;影响大小[ES],-0.35),减少了紧张的精神状态(POMS:BGD,-0.79; 95%CI,-1.38至-0.19; ES,-0.39),并且整体健康状况(BGD,6.45; 95%CI,3.93至8.98; ES,0.75)和性欲以及关系(BGD,1.06; 95%CI,0.11至2.01; ES,0.35)都有所改善,在12个月时睡眠时间也有所改善(BGD,-0.26; 95%CI,-0.49至-0.02; ES,-0.32 )(所有P<0.05)。在24个月时,CR组体重下降更大比例的同时也增加了活力,减少了情绪障碍(ρ=0.27),改善了整体健康(ρ=-0.27),并且有更好的睡眠质量(ρ=0.28)(所有P<0.01)。

在非肥胖的成年人中,CR对于健康相关的生活质量只有积极的影响,没有负面影响。

原始出处:

Corby K. Martin,Manju Bhapkar,Anastassios G. Pittas,et al.Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults,JAMA Intern Med2016.5.3

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  1. 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    2022-06-15 ms3000001717895016

    心情变好太重要了

    0

  2. 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    2016-10-06 1e10c84am36(暂无匿称)

    文章真心很好,感谢作者

    0

  3. 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likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 08:35:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-08-29 ylzr123

    深入学习,好文值得点赞!

    0

  4. 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likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 08:35:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-07-10 oo902

    热量限制

    0

  5. 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likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 08:35:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-05-09 QQ6709219e

    值得学习,注重生活品质好

    0

  6. 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likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 08:35:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-05-09 jaysppr

    应该是少吃好吧

    0

  7. 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  8. 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  9. 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  10. 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GetPortalCommentsPageByObjectIdResponse(id=1336919, encodeId=eb491336919af, content=<a href='/topic/show?id=91386e25889' target=_blank style='color:#2F92EE;'>#热量限制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67258, encryptionId=91386e25889, topicName=热量限制)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/L2dMhrxjvSWuPWKZZP1I83Rw21EWia7LVTYJibLQkb4oTibrYLwhnAXntTBWR3FruIzKfNMiaBwhYV0AKNmiaNxfialg/132, createdBy=6ea92500119, createdName=ms9608593228839890, createdTime=Mon May 09 07:45:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606907, encodeId=44cd160690e17, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon May 09 07:45:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1613827, encodeId=6280161382ea4, content=<a href='/topic/show?id=d87e6e25687' target=_blank style='color:#2F92EE;'>#热量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67256, encryptionId=d87e6e25687, topicName=热量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bba919440409, createdName=ms2536978994064944, createdTime=Mon May 09 07:45:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84671, encodeId=6ea4846e12d, content=超级好的app, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 08:35:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-05-08 stead

    超级好的app

    0

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