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Hypertension:慢性肾脏病患儿的血管硬化程度如何?

2017-04-04 xing.T MedSci原创

在轻度肾功能不全的儿童队列中,动脉硬化程度与正常儿童相比相当。未来的研究需要研究慢性肾脏疾病进展对儿童动脉硬化程度和相关心血管参数的影响。

颈-股动脉脉搏波速度(cfPWV)是一种测量动脉硬化程度的指标,与一般人群血管事件和成人慢性肾脏病相关。然而,很少有关于儿童慢性肾脏病患者的cfPWV的数据。近日,血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在将CKiD队列研究(儿童慢性肾脏病研究)中儿童的cfPWV与健康儿童的规范性数据相比较,并且评估与cfPWV升高的相关风险因素。

研究人员计算了身高/性别和年龄/性别的cfPWV的Z评分,并和已发表的正常儿童标准进行比较。采用多变量线性回归分析来评估cfPWV与年龄、性别、种族、体重指数、诊断、尿蛋白-肌酐比、平均动脉压、心率、抗高血压药物数量、尿酸、血清低密度脂蛋白之间的相关性。

该研究共测量了95名参与者的cfPWV,60%为男性,19%为黑人,46%的CKD由肾小球疾病引起,22%的尿蛋白/肌酐比在0.5至2mg/mg之间,9%的参与者>2mg/mg,平均年龄为15.1岁,平均动脉压为80mmHg,中位数肾小球滤过率为63mL/min/1.73m2。平均cfPWV为5m/s(SD为0.8m/s);平均身高/性别的cfPWV的Z评分数为-0.1(SD为1.1)。在多变量分析中,cfPWV随着年龄、平均动脉压和黑色人种显著增加;没有其他变量,包括肾小球滤过率,与cfPWV独立相关。

在轻度肾功能不全的儿童队列中,动脉硬化程度与正常儿童相比相当。未来的研究需要研究慢性肾脏疾病进展对儿童动脉硬化程度和相关心血管参数的影响。

原始出处:

Jonathan D. Savant, et al. Vascular Stiffness in Children With Chronic Kidney Disease.Hypertension. 2017. https://doi.org/10.1161/HYPERTENSIONAHA.116.07653

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    2017-04-13 feather89
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    2017-04-08 laymankey

    感谢分享一下!

    0

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    2017-04-04 komasun

    学习了谢谢分享

    0

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