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Arthritis Rheumatol:骨密度和骨折是否与老年人影像学骨关节炎的发生和进展有关?

2018-10-02 xiangting MedSci原创

这项研究结果提供了高FN-BMD是出现膝关节、髋关节ROA预后风险因素的强有力证据。

这项研究旨在探讨骨密度(BMD)与膝关节、髋关节和手部骨关节炎的发病率和进展之间的纵向关系;以及鹿特丹研究里老年男性、女性好发椎骨、非椎骨骨折与骨关节炎发病率和进展的关系。

共有4,154名受试者,建立基线股骨颈BMD(FN-BMD)的年龄和性别特异性四分位数。根据影像学图像对膝关节、髋关节骨关节炎的发病率和进展、手部骨关节炎的发病率进行评分。使用McCloskey/Kanis方法对好发椎骨骨折进行评分,通过基线访谈报道好发非椎骨骨折。

与最低四分位区间患者相比,FN-BMD最高四分位区间受试者的偶发性膝关节影像学骨关节炎(ROA)风险升高(OR 1.58; 95%CI:1.14-2.18)、偶发性髋关节ROA风险升高(OR 1.57; 95%CI:1.06至2.32)。高FN-BMD与膝关节、髋关节ROA的进展或手部ROA的发病率之间无显著关联。好发椎骨和非椎骨骨折与膝关节或髋关节ROA的发病率或进展无关。然而,椎骨骨折与偶发性手部ROA相关(OR 1.74; 95%CI:1.02至2.98)。

这项研究结果证实了此前的研究,提供了高FN-BMD是出现膝关节、髋关节ROA预后风险因素的强有力证据。椎骨骨折是偶发性手部ROA的危险因素。

原始出处:

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    2019-04-21 lisa438
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    2018-10-04 lmm397
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    2018-10-04 zhaojie88
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    2018-10-02 121bec68m06(暂无昵称)

    好内容

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2026590, encodeId=fb5320265902a, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Sun Apr 21 10:41:00 CST 2019, time=2019-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972544, encodeId=76b419e2544ce, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Wed Jul 31 22:41:00 CST 2019, time=2019-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265813, encodeId=8fd312658136f, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Oct 04 10:41:00 CST 2018, time=2018-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356945, encodeId=58671356945e9, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Oct 04 10:41:00 CST 2018, time=2018-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347692, encodeId=e71d34e692e9, content=好内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e312278727, createdName=121bec68m06(暂无昵称), createdTime=Tue Oct 02 22:07:58 CST 2018, time=2018-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347689, encodeId=c7bb34e68933, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Oct 02 21:09:41 CST 2018, time=2018-10-02, status=1, ipAttribution=)]
    2018-10-02 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦

    0

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