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Heart：不育症治疗生产的活产婴儿先天性心脏病风险分析!

2017-11-17 xing.T MedSci原创

不育症先天性心脏病风险
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由此可见，该研究结果表明接受所有类型的不孕症治疗后，婴儿的CCHD风险增加。

近日，心血管领域权威杂志Heart上发表了研究文章，该研究旨在评估不同类型的不育症治疗生产的活产婴儿发生紫绀型先天性心脏病（CCHDs）的风险。

该研究对2011年-2014年期间美国的活产婴儿进行了横断面分析。研究人员根据出生证明将不孕症治疗分为以下两组：辅助生殖技术（ART）生育治疗（手术摘除卵子;例如在体外受精和配子内输卵管移植）和非ART生育治疗（如药物治疗和子宫内授精）。研究人员比较了ART和非ART生育治疗组以及那些母亲没有接受过生育治疗并且自然怀孕（NC）的婴儿发生CCHD的风险。

从2011年至2014年期间，共有14242267名活产新生儿，ART生育治疗生育有101494名新生儿，另外，81242名新生儿是由于非ART生育治疗。ART和非ART以及NC组的CCHD患病率分别为393/100892（0.39％），210/80884（0.26％）和10749/14020749（0.08％）。与自然怀孕的婴儿相比，出生于ART的婴儿（调整后的相对危险度（aRR）为2.4,95％可信区间为2.1-2.7）和非ART的婴儿（aRR为1.9,95％可信区间为1.6-2.2）的CCHD风险显著增加。由于ART和非ART治疗的CCHD绝对风险增加分别为0.03％和0.02％。当分析仅限于双胞胎、出生体重在1500克以下和胎龄小于32周的新生儿时，观察到了相似的关系。

由此可见，该研究结果表明接受所有类型的不孕症治疗后，婴儿的CCHD风险增加。

原始出处：
 
Alireza A Shamshirsaz, et al. Cyanotic congenital heart disease following fertility treatments in the United States from 2011 to 2014.heart. 2017. http://dx.doi.org/10.1136/heartjnl-2017-312015
 
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    2017-11-19 zhaojie88

    #ART#

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    2017-11-19 huirong

    #先天性#

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    2017-11-19 ms1343860338762272

    #生产#

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    2017-11-19 mgqwxj

    #心脏病风险#

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    2017-11-19 slcumt

    #HEART#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1356574, encodeId=4ea413565e46f, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Nov 19 02:49:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369322, encodeId=ed04136932231, content=<a href='/topic/show?id=bc9f28589d0' target=_blank style='color:#2F92EE;'>#先天性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28589, encryptionId=bc9f28589d0, topicName=先天性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a435298, createdName=huirong, createdTime=Sun Nov 19 02:49:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517742, encodeId=0aa6151e74281, content=<a href='/topic/show?id=44156886664' target=_blank style='color:#2F92EE;'>#生产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68866, encryptionId=44156886664, topicName=生产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37a111112788, createdName=ms1343860338762272, createdTime=Sun Nov 19 02:49:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559714, encodeId=ffed1559e14ec, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51623, encryptionId=b8435162302, topicName=心脏病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94f015012402, createdName=mgqwxj, createdTime=Sun Nov 19 02:49:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562746, encodeId=7d191562e46c8, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sun Nov 19 02:49:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565723, encodeId=906e1565e234d, content=<a href='/topic/show?id=b8435162302' target=_blank style='color:#2F92EE;'>#心脏病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51623, encryptionId=b8435162302, topicName=心脏病风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94f015012402, createdName=mgqwxj, createdTime=Sun Nov 19 02:49:00 CST 2017, time=2017-11-19, status=1, ipAttribution=)]
    2017-11-19 mgqwxj

    #心脏病风险#

    0

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