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J Biol Dyn:模拟分析环境污染条件下医院中耐甲氧西林金黄色葡萄球菌的季节性感染

2018-08-30 MedSci MedSci原创

美国佛罗里达州迈阿密大学数学系的Huang Q近日在J Biol Dyn杂志上发表了一项研究,他们建立了具有周期性抗生素处方率的数学模型,来研究抗生素滥用和环境污染条件下耐甲氧西林金黄色葡萄球菌(MRSA)的季节性感染。

美国佛罗里达州迈阿密大学数学系的Huang Q近日在J Biol Dyn杂志上发表了一项研究,他们建立了具有周期性抗生素处方率的数学模型,来研究抗生素滥用和环境污染条件下耐甲氧西林金黄色葡萄球菌(MRSA)的季节性感染

在计算周期性模型的起始复制数时,是基于入院时患者没有使用抗生素这一假设。关于一些基本参数主要来源于灵敏度分析。

结果表明,如果基本再生数小于1,那么感染将逐渐消失。如果大于1,则感染将持续存在。数值模拟表明,环境清洁是控制感染的最重要干预措施,这提示,环境污染对MRSA感染具有重要的影响。同样重要的是,有效的抗菌药物治疗也具有十分重要的作用。因此,作者建议,入院时应该进行主动筛查,对阳性病例进行隔离,这样可以快速有效地治疗患者。

原文出处:

Huang, Q., et al., Modeling the seasonality of Methicillin-resistant Staphylococcus aureus infections in hospitals with environmental contamination. J Biol Dyn, 2018: p. 1-24.

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    2018-10-17 一叶知秋
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    2018-09-01 30397606
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