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Int J Nanomed:石墨烯衍生物可促进骨组织再生

2017-08-23 MedSci MedSci原创

石墨烯及其衍生物由于其优异的特性,例如广泛的比表面积和优异的机械性能而在骨组织工程中的应用越来越受到关注。在本研究中,研究人员制备了石墨烯增强纳米羟基磷灰石/聚酰胺66(nHA/PA66)骨螺钉。扫描电子显微镜观察和X射线衍射数据的结果表明,石墨烯和nHA在PA66基体中具有良好的分散性。此外,复合材料的拉伸强度和弹性模量分别显着提高了49.14%和21.2%。与nHA/PA66复合材料相比,鼠骨

石墨烯及其衍生物由于其优异的特性,例如广泛的比表面积和优异的机械性能而在骨组织工程中的应用越来越受到关注。

在本研究中,研究人员制备了石墨烯增强纳米羟基磷灰石/聚酰胺66(nHA/PA66)骨螺钉。扫描电子显微镜观察和X射线衍射数据的结果表明,石墨烯和nHA在PA66基体中具有良好的分散性。此外,复合材料的拉伸强度和弹性模量分别显着提高了49.14%和21.2%。

与nHA/PA66复合材料相比,鼠骨髓间充质干细胞系C3H10T1/2在石墨烯增强的nHA/PA66复合材料中表现出更好的粘附和增殖。荧光染色和细胞活力测定发现细胞伸展出更多的伪足,细胞密度更大,细胞骨架结构更可区分。在成骨分化培养基中培养C3H10T1/2细胞7天和14天后,与石墨烯增强的nHA / PA66共培养的细胞中骨分化相关基因表达,碱性磷酸酶和骨钙素显著增加。

该结果表明该复合材料的骨诱导特性,这一发现经茜素红染色得到进一步支持。另外,将石墨烯增强的nHA/PA66骨螺钉植入犬股骨髁上,术后组织学显示对肝、脾、肾、脑或其他主要器官无明显损害。植入物周围的骨组织生长良好并与其直接相连。软组织无明显炎症反应,这表明螺杆生物相容性良好。

总之,这些观察结果表明,石墨烯增强的nHA/PA66复合材料在骨组织工程中具有很大的应用潜力。

原始出处:

Shiyang Zhang, Qiming Yang, et al., In vitro and in vivo biocompatibility and osteogenesis of graphene-reinforced nanohydroxyapatite polyamide66 ternary biocomposite as orthopedic implant material. Int J Nanomedicine. 2016; 11: 3179–3189.

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    2017-08-24 135****7952平儿

    学了..........

    0

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    2017-08-23 1561ea48efm

    溶骨性骨转移会收益吗?

    0

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    2017-08-23 半夏微凉

    学习了谢谢分享

    0

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    2017-08-23 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

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