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CURR BIOL:美国专家通过刺激迷走神经，唤醒了沉睡了15年的植物人

2017-09-26 MedSci MedSci原创

植物人状态神经刺激恢复意识
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15年前的一场车祸使保罗一直处于植物人状态，神经外科医生将迷走神经刺激器植入到他的胸膛后出现了有意识的迹象。发表于《当代生物学》杂志上的研究结果表明，迷走神经刺激(VNS)是一种用于治疗癫痫和抑郁的方法，此次研究表明VNS有助于恢复意识，对于多年处于植物人状态的患者也有积极作用。

15年前的一场车祸使保罗一直处于植物人状态，神经外科医生将迷走神经刺激器植入到他的胸膛后出现了有意识的迹象。发表于《当代生物学》杂志上的研究结果表明，迷走神经刺激(VNS)是一种用于治疗癫痫和抑郁的方法，此次研究表明VNS有助于恢复意识，对于多年处于植物人状态的患者也有积极作用。

研究人员表示，“一般情况下，植物人状态超过12个月是不可逆的，然而，通过刺激迷走神经，我们发现了改善植物人世界的可能性，迷走神经连接大脑和身体的其他部位，包括肠道。在醒着的时候，它有助于维持重要的警觉性和许多其他重要的功能。

在此次研究中，他们看一个病人躺在病床上十多年没有改善的迹象，因此决定测试VNS恢复意识的能力，经过一个月的迷走神经神经刺激，研究人员注意到病人的运动和大脑活动显着提高，保罗开始开始出现简单的回应，以前这是不可能的。例如，他可以根据指令活动他的眼睛，或者他的头。

刺激后，研究人员还发现一直缺席的“威胁”反应。例如，当医生的头突然走近病人的脸时，他瞪大了眼睛出现惊讶的反应。经过许多年的植物人状态，他已经进入了一个最小意识状态。除此之外，大脑的活动也揭示了重大变化。θ脑电波信号是区分植物人和最小意识状态的显着标志，结果证明大脑区域参与运动、感觉、意识增加。手脚也增加了大脑的连接功能。PET扫描显示，大脑的皮质和皮质下区域代谢活动增加。

原始出处：
 Corazzol,Guillaume Lio, Arthur Lefevre, et al.Restoring consciousness with vagus nerve stimulation，Current Biology, Volume 27, Issue 18, 25 September 2017, Pages R994–R996http://www.cell.com/current-biology/fulltext/S0960-9822(17)30964-8 , DOI: 10.1016/j.cub.2017.07.060

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    2018-11-04 紫辰

    国内什么时候能用到啊

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    2018-05-12 xuyong535

    #植物#

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    2018-03-03 仁医06

    #植物人#

    0

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    2018-06-11 12498ebem31暂无昵称

    #Biol#

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    2018-07-30 sunylz

    #Bio#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=351517, encodeId=737235151e98, content=国内什么时候能用到啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/D9EC9627E4D6FB9F5005617B2A4C5FF0/100, createdBy=2fa42476390, createdName=紫辰, createdTime=Sun Nov 04 13:25:35 CST 2018, time=2018-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745260, encodeId=d4c81e452601a, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Sat May 12 09:15:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008954, encodeId=97a22008954c8, content=<a href='/topic/show?id=4875626990e' target=_blank style='color:#2F92EE;'>#植物人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62699, encryptionId=4875626990e, topicName=植物人)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Mar 03 05:15:00 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767243, encodeId=3d5b1e6724359, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Jun 11 21:15:00 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917683, encodeId=0b99191e68362, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Jul 30 11:15:00 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247888, encodeId=22bb24e88819, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Sep 26 13:22:41 CST 2017, time=2017-09-26, status=1, ipAttribution=)]
    2017-09-26 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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