Baidu
map

Neurology:甘油三酯增加与脑小血管疾病相关

2014-10-31 cath 编译 医学论坛网

法国学者对血脂和脑小血管疾病的关系进行了探讨,结果表明,甘油三酯增加与MRI标志物确定的脑小血管疾病有相关性。相关论文10月15日在线发表于《神经病学》(Neurology)杂志。 研究纳入了2608例来自基于人群队列受试者,其中1842例来自3C-Dijon研究,其余766来自血管老化流行病学研究。分别对每项研究进行分析,并混合使用反向方差荟萃分析。对血脂成分作为连续变量进行研究,这些

法国学者对血脂脑小血管疾病的关系进行了探讨,结果表明,甘油三酯增加与MRI标志物确定的脑小血管疾病有相关性。相关论文10月15日在线发表于《神经病学》(Neurology)杂志。

研究纳入了2608例来自基于人群队列受试者,其中1842例来自3C-Dijon研究,其余766来自血管老化流行病学研究。分别对每项研究进行分析,并混合使用反向方差荟萃分析。对血脂成分作为连续变量进行研究,这些成分包括甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇。校正年龄和性别后对血脂和脑白质高信号(WMHV)的关系进行评估。

结果显示,甘油三酯增加与WMHV体积较大有关,还与腔隙性病灶更为高发有关。在校正其他血管危险因素或炎症标志物后,上述相关性减弱但仍存在。

在应用和不应用降脂药的受试者中,这一相关性均存在,其趋势也相同,但在前者的年龄相关最高四分位数中更为显著。低密度脂蛋白胆固醇水平增加倾向于与所有MRI标志物确定的脑小血管疾病频率和严重度降低有关。

原始出处:

Schilling S1, Tzourio C1, Dufouil C1, Zhu Y1, Berr C1, Alpérovitch A1, Crivello F1, Mazoyer B1, Debette S2.Plasma lipids and cerebral small vessel disease.Neurology. 2014 Oct 15. pii: 10.1212/WNL.0000000000000980. [Epub ahead of print]


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1774643, encodeId=509c1e74643db, content=<a href='/topic/show?id=d0e24e171d1' target=_blank style='color:#2F92EE;'>#小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47171, encryptionId=d0e24e171d1, topicName=小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c7a38663370, createdName=kord1995, createdTime=Fri Aug 28 00:27:00 CST 2015, time=2015-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999457, encodeId=1196199945ef6, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Sep 30 10:27:00 CST 2015, time=2015-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13253, encodeId=0542132532e, content=甘油三酯增加与WMHV体积较大有关,还与腔隙性病灶更为高发有关。在校正其他血管危险因素或炎症标志物后,上述相关性减弱但仍存在。, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Fri Dec 19 06:34:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480852, encodeId=ff3e148085236, content=<a href='/topic/show?id=de508482e61' target=_blank style='color:#2F92EE;'>#脑小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84827, encryptionId=de508482e61, topicName=脑小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76c57719730, createdName=thinkibmz_44722596, createdTime=Sun Nov 02 00:27:00 CST 2014, time=2014-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497846, encodeId=074b149e846df, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Nov 02 00:27:00 CST 2014, time=2014-11-02, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1774643, encodeId=509c1e74643db, content=<a href='/topic/show?id=d0e24e171d1' target=_blank style='color:#2F92EE;'>#小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47171, encryptionId=d0e24e171d1, topicName=小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c7a38663370, createdName=kord1995, createdTime=Fri Aug 28 00:27:00 CST 2015, time=2015-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999457, encodeId=1196199945ef6, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Sep 30 10:27:00 CST 2015, time=2015-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13253, encodeId=0542132532e, content=甘油三酯增加与WMHV体积较大有关,还与腔隙性病灶更为高发有关。在校正其他血管危险因素或炎症标志物后,上述相关性减弱但仍存在。, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Fri Dec 19 06:34:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480852, encodeId=ff3e148085236, content=<a href='/topic/show?id=de508482e61' target=_blank style='color:#2F92EE;'>#脑小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84827, encryptionId=de508482e61, topicName=脑小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76c57719730, createdName=thinkibmz_44722596, createdTime=Sun Nov 02 00:27:00 CST 2014, time=2014-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497846, encodeId=074b149e846df, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Nov 02 00:27:00 CST 2014, time=2014-11-02, status=1, ipAttribution=)]
    2015-09-30 yinhl1978
  3. [GetPortalCommentsPageByObjectIdResponse(id=1774643, encodeId=509c1e74643db, content=<a href='/topic/show?id=d0e24e171d1' target=_blank style='color:#2F92EE;'>#小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47171, encryptionId=d0e24e171d1, topicName=小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c7a38663370, createdName=kord1995, createdTime=Fri Aug 28 00:27:00 CST 2015, time=2015-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999457, encodeId=1196199945ef6, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Sep 30 10:27:00 CST 2015, time=2015-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13253, encodeId=0542132532e, content=甘油三酯增加与WMHV体积较大有关,还与腔隙性病灶更为高发有关。在校正其他血管危险因素或炎症标志物后,上述相关性减弱但仍存在。, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Fri Dec 19 06:34:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480852, encodeId=ff3e148085236, content=<a href='/topic/show?id=de508482e61' target=_blank style='color:#2F92EE;'>#脑小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84827, encryptionId=de508482e61, topicName=脑小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76c57719730, createdName=thinkibmz_44722596, createdTime=Sun Nov 02 00:27:00 CST 2014, time=2014-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497846, encodeId=074b149e846df, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Nov 02 00:27:00 CST 2014, time=2014-11-02, status=1, ipAttribution=)]
    2014-12-19 rosa00tong

    甘油三酯增加与WMHV体积较大有关,还与腔隙性病灶更为高发有关。在校正其他血管危险因素或炎症标志物后,上述相关性减弱但仍存在。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1774643, encodeId=509c1e74643db, content=<a href='/topic/show?id=d0e24e171d1' target=_blank style='color:#2F92EE;'>#小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47171, encryptionId=d0e24e171d1, topicName=小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c7a38663370, createdName=kord1995, createdTime=Fri Aug 28 00:27:00 CST 2015, time=2015-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999457, encodeId=1196199945ef6, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Sep 30 10:27:00 CST 2015, time=2015-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13253, encodeId=0542132532e, content=甘油三酯增加与WMHV体积较大有关,还与腔隙性病灶更为高发有关。在校正其他血管危险因素或炎症标志物后,上述相关性减弱但仍存在。, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Fri Dec 19 06:34:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480852, encodeId=ff3e148085236, content=<a href='/topic/show?id=de508482e61' target=_blank style='color:#2F92EE;'>#脑小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84827, encryptionId=de508482e61, topicName=脑小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76c57719730, createdName=thinkibmz_44722596, createdTime=Sun Nov 02 00:27:00 CST 2014, time=2014-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497846, encodeId=074b149e846df, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Nov 02 00:27:00 CST 2014, time=2014-11-02, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1774643, encodeId=509c1e74643db, content=<a href='/topic/show?id=d0e24e171d1' target=_blank style='color:#2F92EE;'>#小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47171, encryptionId=d0e24e171d1, topicName=小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c7a38663370, createdName=kord1995, createdTime=Fri Aug 28 00:27:00 CST 2015, time=2015-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999457, encodeId=1196199945ef6, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Sep 30 10:27:00 CST 2015, time=2015-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13253, encodeId=0542132532e, content=甘油三酯增加与WMHV体积较大有关,还与腔隙性病灶更为高发有关。在校正其他血管危险因素或炎症标志物后,上述相关性减弱但仍存在。, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=870092288, createdName=rosa00tong, createdTime=Fri Dec 19 06:34:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480852, encodeId=ff3e148085236, content=<a href='/topic/show?id=de508482e61' target=_blank style='color:#2F92EE;'>#脑小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84827, encryptionId=de508482e61, topicName=脑小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76c57719730, createdName=thinkibmz_44722596, createdTime=Sun Nov 02 00:27:00 CST 2014, time=2014-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497846, encodeId=074b149e846df, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Nov 02 00:27:00 CST 2014, time=2014-11-02, status=1, ipAttribution=)]

相关资讯

Hypertension:父母高血压影响后代血压及代谢

  日本学者的一项研究表明,父母高血压对血压、血糖和甘油三酯水平升高具有年龄非依赖性影响,这可能解释了高血压家族史者心血管事件升高。论文于2012年9月24日在线发表于《高血压》(Hypertension)杂志。   目前尚不清楚父母高血压与后代心血管事件的相关性。此项研究共纳入2607例(男性1095例,女性1512例)具备父母高血压病史的受试者,并利用混合效应模型评估双亲高血压对血压和代谢指

EASD 2013:高甘油三酯血症与2型糖尿病患者并发症的关系

在9月23日至27日召开的欧洲糖尿病研究学会(EASD)第49届年会上,一项意大利的多中心研究报告指出,高甘油三酯(HTG)与所有的CKD 表型有联系、不依赖他汀类药治疗,而后者与心血管疾病(CVD)有联系、不依赖甘油三酯(TG)水平。这些数据指出HTG在慢性肾病(CKD)发生中可能的作用,和治疗致动脉粥样硬化的血脂异常的重要性。 致动脉粥样硬化的血脂异常,即高甘油三

Atherosclerosis:HDL-C、甘油三酯和颈总动脉内膜中层厚度:21 000例患者数据荟萃分析

低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C),而非甘油三酯(TG)水平,是未来心血管事件标志物。颈总动脉(CCA)内膜中层厚度(IMT)与卒中和心肌梗死发生率升高相关。然而,尚缺乏血浆HDL-C和(或)TG水平与IMT相关性信息。2014年欧洲卒中大会(ESC)上,法国INSERM U698巴黎法国神经病和卒中中心P.J.Touboul等报告的荟萃分析纳入6项大规模观察性研究

Diabetes Care:母体血脂影响胎儿生长发育

为了研究母体血液循环中“燃料”与新生儿大小间的关系,并比较血糖和脂质的相对影响。来自印度浦那爱德华国王纪念医院研究中心Kamalnayan Bajaj 糖尿病学研究中心的Kulkarni等进行了一项研究,研究发现,除了已经明确的血糖对新生儿的影响,母体脂质对新生儿大小也有一定的影响。研究结果在线发表于2013年6月11日美国的《糖尿病治疗》(Diabetes Care)杂志上。 浦那母体营养研究

HCS研究:甘油三酯独立预测心血管事件

  8月28日,在欧洲心脏病学会(ESC2011)心血管危险和并发症热点研究报告会上,德国学者Ulrich Laufs报告的一项前瞻性研究表明,空腹和餐后甘油三酯(TG)水平可独立预测葡萄糖耐量正常冠心病患者的心血管事件。   空腹血清TG测定对血糖正常和糖耐量受损心血管高危患者的危险预测作用,以及餐后血清TG是否为二级预防的风险修正因子均尚未明确。研究连续纳入514例经血管造影确认的

Baidu
map
Baidu
map
Baidu
map