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Nature & Science:科学家为克隆胚胎干细胞“突破”辩解

2013-05-28 Nature & Science 生物360

随着科学界对胚胎干细胞“突破性成果”的质疑,继在接受英国《自然》杂志采访后,论文作者又通过另一著名学术期刊《科学》杂志辩解:论文确实有错,但对研究结果无影响,论文快速发表或是因为《细胞》杂志担心论文消息泄漏。 一周前,美国俄勒冈州健康和科学大学国家灵长类研究中心舒赫拉特·米塔利波夫等人在《细胞》杂志网络版上发表论文称,通过向剔除细胞核物质的卵细胞内植入皮肤细胞,成功培育出了人类胚胎干细胞。但后来

随着科学界对胚胎干细胞“突破性成果”的质疑,继在接受英国《自然》杂志采访后,论文作者又通过另一著名学术期刊《科学》杂志辩解:论文确实有错,但对研究结果无影响,论文快速发表或是因为《细胞》杂志担心论文消息泄漏。

一周前,美国俄勒冈州健康和科学大学国家灵长类研究中心舒赫拉特·米塔利波夫等人在《细胞》杂志网络版上发表论文称,通过向剔除细胞核物质的卵细胞内植入皮肤细胞,成功培育出了人类胚胎干细胞。但后来有匿名读者指出论文存在“图片重复使用”等问题,更让科学界震惊的是,论文提交仅4天就被接受。这一成果陷入质疑之中。

米塔利波夫和《细胞》杂志23日均表示,论文只有“一些小的错误”,相信不影响研究结果。但对《细胞》为什么快速发表论文,他们的解释并不让人信服。米塔利波夫对《自然》杂志称,是希望能在今年6月的一个干细胞研究国际会议上提交这一成果,而《细胞》的理由则包括论文重要和审稿人权威,等等。

对此,米塔利波夫对《科学》杂志作了进一步解释。他说,尽管他对《自然》杂志提到了6月的国际会议,但这不是快速发表的理由,也不是因为其他研究小组的竞争。论文提交日期显示为4月30日,但他在此5、6天前就提交给了《细胞》。编辑们表示感兴趣后,他才于4月30日正式提交。

米塔利波夫称,《细胞》杂志要求审稿人快速审稿,“所以他们一天之内就审完了”,只提出一些小的修改意见,因此很快改完。“《细胞》杂志可能担心论文消息泄漏,所以接受之后很快在线发表了”。

值得关注的是,米塔利波夫似乎对质疑“图片重复使用”的读者颇有微词。他说,“肉眼很难看出它们是同一张图片或不同的图片”,因此他感到好奇的是,提出问题的读者是否使用了图像检查软件,“我多希望曾用这种软件检查一下我们的论文”。

两个因素使米塔利波夫的成果引人注目:首先这是第一次采用克隆技术制造人类胚胎干细胞,可能引发“克隆人”隐忧;其次他们的成果与8年前韩国黄禹锡造假事件很相似。米塔利波夫接受《自然》、《科学》两份影响最大的综合性学术期刊采访,看来是希望至少在业内尽快平息风波。

原文检索:

ScienceInsider: Mislabeled Images Bedevil Landmark Cloning Paper

NatureNews: Stem-cell cloner acknowledges errors in groundbreaking paper

Cell: Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer. 

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    2014-04-02 aids221
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    2013-06-07 liye789132251
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    2013-05-30 ailian1202
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    2013-05-30 jichang

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  美国一研究小组近日在《细胞》杂志发表论文称,成功培育出了人类胚胎干细胞。但很快就有读者指控论文存在“图片重复使用”等问题。《细胞》杂志已证实正在对此事件进行调查。  据美国《科学》杂志网站22日报道,遭受质疑的是美国俄勒冈州健康和科学大学国家灵长类研究中心米塔利波夫领导的研究小组。他们5月15日在《细胞》杂志上发表论文称,通过向剔除细胞核物质的卵细胞内植入皮肤细胞,成功培育出了人类胚胎干细胞。

美国实施首例利用胚胎干细胞医治失明手术

来源:科技日报     据美国《华盛顿邮报》及《技术评论杂志》在线版7月15日消息,美国于近日正式进行了首例以人类胚胎干细胞医治渐进式失明患者的手术。这是美国食品和药物管理局(FDA)批准的第二起人类胚胎干细胞人体临床试验。而本次手术治疗备受重视,被认为是干细胞领域的重要里程碑,或将使饱受争议的人类胚胎干细胞研究证明其真实价值。   

Mol Cell:胚胎干细胞可以感知DNA损伤发生“自杀”行为

图中显示,在胚胎干细胞中,激活的Bax蛋白(红色)可以定位在高尔基体中;蓝色的为细胞核 (Credit: Deshmukh Lab, UNC-Chapel Hill) 胚胎干细胞可以在机体中分化成为各种类型的细胞,如果胚胎干细胞在胚胎发育过程中遭受损伤,它们为了胚胎的正常发育会很快“自我了断”,这项来自北卡罗来纳大学研究者的研究成果刊登在了近日的国际杂志Molecular Cell上。这项研究发

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