BMJ：他汀类药物可显著降低75-84岁老年糖尿病患者动脉粥样硬化风险

2018-09-06 zhangfan MedSci原创

研究认为，他汀类对75-84糖尿病患者动脉粥样硬化性心血管疾病的保护作用最为显著，但对于非糖尿病患者以及85岁以上老年人群的效果不明显

近日研究人员考察了他汀治疗对降低高龄老年人群动脉粥样硬化性心血管疾病(CVD)风险的效果。

SIDIAP研究在西班牙开展，46864名75岁以上无临床确诊性动脉粥样硬化性CVD人群参与研究，依据是否患有II型糖尿病和先前是否接受过他汀治疗分层。研究的主要终点为动脉粥样硬化性CVD及全因死亡率。

参与者平均年龄77岁，女性占63%，平均随访5.6年。对于75-84岁的非糖尿病人群，接受他汀治疗后动脉粥样硬化性CVD风险为0.94，全因死亡风险为0.98；而对于85岁以上非糖尿病老人则为0.93和0.97。对于糖尿病患者，75-84岁老年人接受他汀治疗后动脉粥样硬化性CVD风险为0.76，全因死亡风险为0.84；对于85岁以上老年人则为0.82和1.05。对于非糖尿病患者，他汀类药物对动脉粥样硬化性CVD的保护作用不显著，而对于75-84岁糖尿病患者他汀类药物对动脉粥样硬化性CVD的保护作用明显，但随着糖尿病老人年龄增大，这种保护作用逐渐减弱，在90岁消失。

研究认为，他汀类对75-84糖尿病患者动脉粥样硬化性心血管疾病的保护作用最为显著，但对于非糖尿病患者以及85岁以上老年人群的效果不明显。

原始出处：

Rafel Ramos et al. Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes： retrospective cohort study. BMJ. 05 September 2018.

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2019-01-29 gaoxiaoe

#BMJ#

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2019-08-08 ms6390871039024434

#他汀类药#

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2019-04-15 huangshifeng

#粥样硬化#

55 0
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2018-09-08 xue8604

#糖尿病患者#

51 0
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2018-09-08 ms3323097325231039

#老年糖尿病#

84 0
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2018-09-06 1e145228m78(暂无匿称)

学习了，谢谢作者分享!

93 0
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2018-09-06 misszhang

谢谢MedSci提供最新的资讯

105 0

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BMJ：他汀类药物可显著降低75-84岁老年糖尿病患者动脉粥样硬化风险

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