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PLos One:心脏手术后急性肾损伤患者的围手术期体重变化与院内死亡率相关

2017-11-22 xiangting MedSci原创

对于需要RRT的AKI心脏手术患者,围手术期的体重变化与术后30天死亡风险升高独立相关。

心脏手术(CS)后的术后急性肾损伤(AKI)很常见。体重(BW)可以通过代表营养和流体状态的总和而变化。然而,有严重术后AKI的CS患者围术期BW变化的预测作用尚未被探讨过。这项研究旨在评估这种关联。

这项研究使用前瞻性收集的多中心队列,NSARF(台湾大学医院急性肾衰研究组)数据库。纳入标准:于2001年1月至2014年1月在重症监护病房住院,术后AKI需要肾脏替代治疗(RRT)的成人CS患者,初始意识清晰,住院14天内接受CS,CS治疗后7 天内接受RRT。以30天的术后死亡率为终点,评估了代表流体状态的临床因素和患者结局之间的关联。

共有188名患者(70名女性,平均年龄63.7±15.2岁)入组。与幸存者(n = 124)相比,非存活者(n = 64)的围手术期BW变化明显较高[3.6±6.1%vs.0.1±8.3%,p = 0.003],而不是术后和RRT前的BW变化。采用多变量Cox比例风险模型,术后30天的死亡率的独立指标包括围手术期BW改变(p = 0.026)和包装红细胞输注(p = 0.007),术后主动脉内球囊反搏(p = 0.001)和中心静脉压水平(p = 0.005),以及心率(p= 0.022),连续性器官衰竭评分(p <0.001),logistic器官功能障碍评分(p = 0.001)和RRT开始时的血总胆红素水平(p = 0.044)。广义加法模型进一步表明以多元方式,围手术期体重变化在2%至15%之间时,死亡风险显著升高。

对于需要RRT的AKI心脏手术患者,围手术期的体重变化与术后30天死亡风险升高独立相关。

原始出处:

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    2017-11-22 changjiu

    学习一下谢谢

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