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GUT:40年随访确证炎症性肠病患者帕金森风险增加

2018-05-22 zhangfan MedSci原创

研究发现炎症性肠病患者的后继帕金森风险增加

动物模型研究发现,肠道炎症在帕金森(PD)及多系统萎缩症(MSA)的进展过程中发挥了关键作用。近日研究人员就真实世界中炎症性肠病IBD)患者的PD及MSA风险进行了考察。

研究考察了1977-2014年间丹麦IBD患者(n=76477)资料,同时招募了7548259名年龄性别相匹配的非IBD志愿者作为对照组,比较IBD以及非IBD人群PD及MSA风险差异。

统计发现,IBD患者相对非IBD人群其PD风险增加22%,其风险增加与IBD确诊年龄、性别以及随访时间长度无关。参与者队列中总MSA发病率较低,但IBD患者的MSA风险较非IBD人群增加41%。总体上,风险增加与性别无关,但溃疡性结肠炎患者的帕金森神经机能障碍风险显著增加(HR=1.35; 95% CI 1.20-1.52),而PD与克罗恩病(HR=1.12; 95% CI 0.89-1.40)之间的相关性则不显著。

研究发现,炎症性肠病患者的后继帕金森风险增加。

原始出处:


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    2018-05-24 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-05-23 深海的鱼

    学习学习学习

    0

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    2018-05-22 cscdliu

    学习了.谢谢

    0

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