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JAMA Intern Med:年轻人的BMI和体质与成人高血压风险相关

2016-01-22 崔倩 译 MedSci原创

较高的身体质量指数(BMI)和低体质是高血压的危险因素,但它们的相互作用是未知的。这些可变的危险因素之间的相互作用的阐明可能有助于易感人群进行更有效的干预措施。该研究的目的是在一项全国大型队列中,确定BMI和体质对高血压的相互作用。本队列研究包括从1969年1月1日到1997年12月31日,来瑞典的1547189名军事义务兵(包括每年所有的18岁男子的97%-98%),随访时间至2012年12月3

较高的身体质量指数(BMI)和较低的体质是高血压的危险因素,但它们的相互作用是未知的。这些可变的危险因素之间的相互作用的阐明可能有助于易感人群进行更有效的干预措施。

该研究的目的是在一项全国大型队列中,确定BMI和体质对高血压的相互作用。

本队列研究包括从1969年1月1日到1997年12月31日,来自瑞典的1547189名军事义务兵(包括每年所有的18岁男子的97%-98%),随访时间至2012年12月31日(最大年龄62岁)。数据分析是在2015年8月1日至8月15日期间进行的。检测指标包括征兵体检时的标准化的有氧能力、肌肉力量、BMI测量。主要成果和措施包括来自门诊和住院确诊的高血压。


在3970万人-年的随访过程中,共有93035人(6.0%)被诊断为高血压。较高的BMI和较低有氧能力(而不是肌肉力量)增加了高血压的风险,且独立于家族历史和社会经济因素(BMI,体重超重或肥胖vs.正常:发病率之比,2.51;95%Cl,2.46-2.55;P<0.001;有氧代谢能力,最低vs.最高的三分位数:发病率之比,1.50;95%Cl,1.47-1.54;P<0.001)。在整个分布中有氧代谢能力与高血压负相关(每100万人的发病率为,0.70;95%CI,0.69-0.71; P<0.001)。较高的BMI(体重超重或肥胖vs.正常)和低有氧能力(最低vs.最高的三分位数)与高血压的最高风险有关(发病率之比,3.53;95%CI,3.41-3.66;P<0.001)并有一个消极递增性和复合交互效应(P <0.001)。虽然较高的BMI是高血压显著的危险因素,但较低的有氧能力也是那些有正常BMI人群的一个显著的危险因素。

在这个全国性大型队列研究中,在青春期后期,较高的BMI和较低的有氧代谢能力均与成年期高血压的风险较高有关。如果被未来的研究确定,该研究结果表明,预防高血压的干预措施,要在生命的早期就开始进行,不仅包括控制体重,还包括有氧健身,即使有正常体重的人也要进行预防。

原始出处:

Casey Crump,Jan Sundquist,Marilyn A. Winkleby,et al.Interactive Effects of Physical Fitness and Body Mass Index on the Risk of Hypertension,JAMA Intern Med,2016.1.19

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    2016-01-27 李继凯

    新想法

    0

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    2016-01-27 I come

    观点新

    0

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    2016-01-27 I come

    好文

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=61106, encodeId=638f611061a, content=新想法, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 18:41:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60159, encodeId=adc3601599b, content=观点新, beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Wed Jan 27 00:10:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60158, encodeId=920d6015832, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Wed Jan 27 00:09:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464290, encodeId=4f711464290c7, content=<a href='/topic/show?id=d26f5393ee4' target=_blank style='color:#2F92EE;'>#成人高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53937, encryptionId=d26f5393ee4, topicName=成人高血压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5516658580, createdName=xiangyuzhou973, createdTime=Sun Jan 24 02:44:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606831, encodeId=b6661606831fe, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Jan 24 02:44:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=58887, encodeId=171a5888e9c, content=有氧代谢能力,这是一个全新的指标非常具有参考价值。, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 23 10:31:00 CST 2016, time=2016-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=58838, encodeId=ff0658838ff, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8941653912, createdName=胖胖7598, createdTime=Fri Jan 22 22:51:00 CST 2016, time=2016-01-22, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=61106, encodeId=638f611061a, content=新想法, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Wed Jan 27 18:41:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60159, encodeId=adc3601599b, content=观点新, beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Wed Jan 27 00:10:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60158, encodeId=920d6015832, content=好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Wed Jan 27 00:09:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464290, encodeId=4f711464290c7, content=<a href='/topic/show?id=d26f5393ee4' target=_blank style='color:#2F92EE;'>#成人高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53937, encryptionId=d26f5393ee4, topicName=成人高血压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5516658580, createdName=xiangyuzhou973, createdTime=Sun Jan 24 02:44:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606831, encodeId=b6661606831fe, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Jan 24 02:44:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=58887, encodeId=171a5888e9c, content=有氧代谢能力,这是一个全新的指标非常具有参考价值。, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 23 10:31:00 CST 2016, time=2016-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=58838, encodeId=ff0658838ff, content=?, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8941653912, createdName=胖胖7598, createdTime=Fri Jan 22 22:51:00 CST 2016, time=2016-01-22, status=1, ipAttribution=)]
    2016-01-23 lovetcm

    有氧代谢能力,这是一个全新的指标非常具有参考价值。

    0

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    2016-01-22 胖胖7598

    ?

    0

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