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JAMA Psychiatry:抗精神病药物对人类脑结构的影响

2020-03-04 MedSci MedSci原创

抗精神病药物可改变人类大脑结构

动物研究发现,抗精神病药物与大脑结构改变有关,近日研究人员评估了抗精神病药物对人类大脑结构的影响。

STOP-PDII研究中,招募18至85岁重度抑郁障碍(精神病性抑郁)患者,研究为期20周,患者在服用奥氮平和舍曲林后精神病缓解和抑郁症缓解/接近缓解至少8周,随后患者在36周内改为服用安慰剂和舍曲林。在基线、36周或疾病复发后进行MRI扫描。研究的主要终点为灰质皮质厚度,次要指标为白质微结构完整性。

88名参与者(年龄范围为18-85岁)完成了基线扫描;75人完成了后续扫描,其中72人(32名男性和40名女性)纳入最终分析。治疗组皮质厚度随着时间的推移有显著的交互作用,而与表面积的交互作用不显著。各向异性分数没有发现明显的相互作用,但白质骨架的平均扩散率存在一个相互作用(t=-2.6)。当分析仅限于那些病情缓解的患者时,与安慰剂相比,奥氮平暴露与左半球(β=0.04 )和右半球(β=0.03)皮质厚度的显著减少有关。事后分析显示,接受安慰剂治疗的复发患者与持续缓解的患者相比,皮质厚度减少。

研究发现,抗精神病药物可改变人类大脑结构。

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    2020-03-06 wmr116
  4. [GetPortalCommentsPageByObjectIdResponse(id=1792165, encodeId=002b1e921656e, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sat Mar 28 19:59:00 CST 2020, time=2020-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1513097, encodeId=76ad151309e2e, content=<a href='/topic/show?id=bdc555596cd' target=_blank style='color:#2F92EE;'>#抗精神病药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55596, encryptionId=bdc555596cd, topicName=抗精神病药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=694d10531994, createdName=12498768m16(暂无昵称), createdTime=Fri Mar 06 09:59:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556511, encodeId=d27815565115a, content=<a href='/topic/show?id=ab7e85001cf' target=_blank style='color:#2F92EE;'>#脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85001, encryptionId=ab7e85001cf, topicName=脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f3114785325, createdName=wmr116, createdTime=Fri Mar 06 09:59:00 CST 2020, time=2020-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035949, encodeId=9a2f10359491b, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Wed Mar 04 21:59:00 CST 2020, time=2020-03-04, status=1, ipAttribution=)]
    2020-03-04 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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