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JCEM:1型糖尿病成人椎体骨折的患病率

2022-02-19 MedSci原创 MedSci原创

研究人员使用mABQ方法评估的脊椎骨折评估结果并未证实1型糖尿病控制相对良好的男性和女性的脊椎骨折患病率有所增加。

据报道,在1型糖尿病的年轻患者中,脊椎骨折的患病率高达24%。如果这种高患病率得到证实,1型糖尿病患者可以从预防性脊椎骨折的筛查工作中受益。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在比较1型糖尿病成人和非糖尿病对照者之间的脊椎骨折的患病率。

这项横断面研究纳入了来自2个三级医疗中心门诊就诊的127名1型糖尿病成人和65名年龄、性别和BMI大小相匹配的对照者。研究人员通过双能X线骨密度仪(DXA)进行的椎体骨折评估,用于常见的脊椎骨折。研究人员采用了改进的基于算法的定性(mABQ)方法进行分析。研究人员通过DXA评估骨矿物质密度(BMD)和骨小梁评分(TBS)。此外,研究人员在一组参与者中测量了血清骨转换标志物和硬化蛋白。

1型糖尿病参与者(70名女性,57名男性)的平均年龄为42.8±14.8岁,中位糖尿病病程为25.8(15.8-34.4)年,平均BMI为26.6±5.4kg/m2,过去3年的平均HbA1c为7.5±0.9%。对照组(35名女性,30名男性)的平均年龄为42.2±15.9岁,平均BMI为26.1±5.1kg/m2。两组之间的脊椎骨折患病率相当(2.4% vs. 3.1%,P=0.99)。1型糖尿病患者与对照组的TBS、全髋关节和股骨颈的BMD以及骨形成和再吸收标志物均较低,而硬化蛋白水平相似。

由此可见,研究人员使用mABQ方法评估的脊椎骨折评估结果并未证实1型糖尿病控制相对良好的男性和女性的脊椎骨折患病率有所增加。

原始出处:

Julie-Catherine Coll.et al.Prevalence of Vertebral Fractures in Adults With Type 1 Diabetes: DenSiFy Study (Diabetes Spine Fractures).JCEM.2022.https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgac031/6517001?redirectedFrom=fulltext&login=false

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    2022-07-16 achengzhao
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    2023-01-28 仁者大医
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    2022-02-25 ms6000001154688722

    学习

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    2022-02-20 ms3000000089219083

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    2022-02-20 1351fc2f66m

    交叉知识,学习学习

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