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Diabetes Care:GDM婴儿可能出现早期肥胖?

2016-05-26 liyue 译 MedSci原创

患有妊娠期糖尿病(GDM)的母亲产下的婴儿将来有着更高的风险出现代谢性问题。研究人员通过选择合理的影响因子、脂肪组织(AT)的重量和分布、肝细胞内脂质(IHCL)含量,比较有GDM和无GDM的产妇产下的婴儿在出生后3个月的差别。该研究为前瞻性的纵向研究,利用MRI和光谱定量分析在出生后、2周、8-12周时检测全身和局部的脂肪体积、IHCL含量。并校正婴儿的体型大小、性别、产妇孕前的BMI。研究人员

患有妊娠期糖尿病(GDM)的母亲产下的婴儿将来有着更高的风险出现代谢性问题。研究人员通过选择合理的影响因子、脂肪组织(AT)的重量和分布、肝细胞内脂质(IHCL)含量,比较有GDM和无GDM的产妇产下的婴儿在出生后3个月的差别。

该研究为前瞻性的纵向研究,利用MRI和光谱定量分析在出生、2周、8-12周时检测全身和局部的脂肪体积、IHCL含量。并校正婴儿的体型大小、性别、产妇孕前的BMI。

研究人员纳入了86例婴儿(GDM组42例,对照组44例)。患有GDM的母亲孕期血糖控制良好。截止第二个随访期,婴儿大部分是母乳喂养(GDM组为71%,对照组为74%)。在年龄中位数11天时,两组的AT体积无统计学差异(P=0.55),但是在年龄中位数10周时,GDM组的婴儿AT体积较大(247 cm3,P=0.01)。校正婴儿体型大小后,10周时GDM组的AT体积较对照组的明显增加(16.0%,95%CI[6.0,27.1],P=0.002)。脂肪组织的分布及IHCL含量在所有时间点两组间均无显著差异。

结论:GDM母亲产下的婴儿在婴儿早期可以出现肥胖,尽管母亲孕期血糖控制良好、并且母乳喂养,但是仍提示今后出现代谢性问题的潜在可能性。产后脂肪组织体积的减少可能是减少健康风险发生的一个治疗目标。

原始出处:

Logan KM,Emsley RJ,Jeffries S,et al.Development of Early Adiposity in Infants of Mothers With Gestational Diabetes Mellitus.Diabetes Care 2016 Jun; 39(6): 1045-1051.

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    2016-06-02 沉心多思

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    2016-05-28 朱睿睿

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