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SCI REP：脓毒症患者短期和长期认知变化的相关因素！

2018-03-14 xing.T MedSci原创

脓毒症短期长期认知变化因素
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一般来说，严重脓毒症或感染性休克患者存在的认知障碍可随着时间的推移而改善。这种改善与他们的ICU停留期间的因素有关，如认知储备、教育水平、在ICU停留期间的平均血糖以及NSE水平。

近日，Scientific reports杂志上发表了一篇研究文章，研究人员的目的是评估严重脓毒症或感染性休克患者的认知情况，以及明确认知功能障碍是否与临床和实验室参数有关。

研究人员对严重败血症和感染性休克患者进行了一项队列研究，在24 h内以及ICU出院后一年进行评估分析。研究人员对受试者人口统计学指标、临床和实验室数据进行了分析，并进行以下神经心理学测验：CERAD、简易精神状态评估以及A型和B型的试路试验。

研究人员纳入了33名患者，平均年龄为49岁，19%为女性。患者在ICU出院后24小时进行了大多数指标测定，随访可以改善。ICU出院时IQCODE、APACHE II评分、NSE和IFN-γ水平均与认知表现较差相关，而较高的教育水平与良好的认知功能有关。首次抗生素治疗时间、ICU停留期间累积的氟哌啶醇剂量及平均血糖也与较差的认知预后有关。

一般来说，严重脓毒症或感染性休克患者存在的认知障碍可随着时间的推移而改善。这种改善与他们的ICU停留期间的因素有关，如认知储备、教育水平、在ICU停留期间的平均血糖以及NSE水平。

原始出处：

Allan J. C. Calsavara,et al. Factors Associated With Short and Long Term Cognitive Changes in Patients With Sepsis.Scientific reports.2018. https://www.nature.com/articles/s41598-018-22754-3

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1812853, encodeId=653c181285367, content=<a href='/topic/show?id=9a0a91225d8' target=_blank style='color:#2F92EE;'>#认知变化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91225, encryptionId=9a0a91225d8, topicName=认知变化)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Jun 04 16:27:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301500, encodeId=458230150054, content=非常好.多谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlnMA4Mv0JEd3wqGB7GHzs1MsciccMzuKz0NRuK1DznR2t4OvibiaIxQF4BD7icaXxtmRtVzoRjzbSbQ/0, createdBy=11672154424, createdName=马路1平, createdTime=Sat Mar 31 14:09:48 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301499, encodeId=8eb330149913, content=已读, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlnMA4Mv0JEd3wqGB7GHzs1MsciccMzuKz0NRuK1DznR2t4OvibiaIxQF4BD7icaXxtmRtVzoRjzbSbQ/0, createdBy=11672154424, createdName=马路1平, createdTime=Sat Mar 31 14:09:26 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457484, encodeId=94b5145e48483, content=<a href='/topic/show?id=4159e25296d' target=_blank style='color:#2F92EE;'>#相关因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72529, encryptionId=4159e25296d, topicName=相关因素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=19655942413, createdName=zzc2213, createdTime=Fri Mar 16 11:27:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516363, encodeId=e8da15163639b, content=<a href='/topic/show?id=a5598519866' target=_blank style='color:#2F92EE;'>#脓毒症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85198, encryptionId=a5598519866, topicName=脓毒症患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dd7310955580, createdName=dlwang_26703130, createdTime=Fri Mar 16 11:27:00 CST 2018, time=2018-03-16, status=1, ipAttribution=)]
    2018-06-04 仁心济世

    #认知变化#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1812853, encodeId=653c181285367, content=<a href='/topic/show?id=9a0a91225d8' target=_blank style='color:#2F92EE;'>#认知变化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91225, encryptionId=9a0a91225d8, topicName=认知变化)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Jun 04 16:27:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301500, encodeId=458230150054, content=非常好.多谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlnMA4Mv0JEd3wqGB7GHzs1MsciccMzuKz0NRuK1DznR2t4OvibiaIxQF4BD7icaXxtmRtVzoRjzbSbQ/0, createdBy=11672154424, createdName=马路1平, createdTime=Sat Mar 31 14:09:48 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301499, encodeId=8eb330149913, content=已读, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlnMA4Mv0JEd3wqGB7GHzs1MsciccMzuKz0NRuK1DznR2t4OvibiaIxQF4BD7icaXxtmRtVzoRjzbSbQ/0, createdBy=11672154424, createdName=马路1平, createdTime=Sat Mar 31 14:09:26 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457484, encodeId=94b5145e48483, content=<a href='/topic/show?id=4159e25296d' target=_blank style='color:#2F92EE;'>#相关因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72529, encryptionId=4159e25296d, topicName=相关因素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=19655942413, createdName=zzc2213, createdTime=Fri Mar 16 11:27:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516363, encodeId=e8da15163639b, content=<a href='/topic/show?id=a5598519866' target=_blank style='color:#2F92EE;'>#脓毒症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85198, encryptionId=a5598519866, topicName=脓毒症患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dd7310955580, createdName=dlwang_26703130, createdTime=Fri Mar 16 11:27:00 CST 2018, time=2018-03-16, status=1, ipAttribution=)]
    2018-03-31 马路1平

    非常好.多谢分享

    0

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    2018-03-31 马路1平

    已读

    0

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    2018-03-16 zzc2213

    #相关因素#

    0

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    2018-03-16 dlwang_26703130

    #脓毒症患者#

    0

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