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Toxicol Sci:肺部炎症诱发全身炎症、内皮功能障碍和胰岛素抵抗

2017-11-19 Emma MedSci原创

肺部不断暴露于周围的细微物质(PM2.5)等环境污染物,使其成为人体最常见的炎症部位之一。

肺部不断暴露于周围的细微物质(PM2.5)等环境污染物,使其成为人体最常见的炎症部位之一。鉴于炎症在心脏代谢疾病发病机制中的关键作用,因此肺部炎症被认为可能是心脏代谢疾病的重要危险因素。

研究人员将SFTPC-rtTA+/-tetO-cre+/-pROSA-inhibitor κB kinase 2(IKK2)ca+/- (LungIKK2ca)和同窝SFTPC-rtTA+/-tetO-cre-/-pROSA-IKK2ca+/- wildtype (WT) 小鼠喂食多西环素以诱导肺中组成性活化的Ikk2(Ikk2ca)过表达,并评估其肺、全身、脂肪和下丘脑炎症、血管功能和葡萄糖稳态。

结果显示,强力霉素饮食导致IKK2ca在LungIKK2ca的肺中过表达,但WT小鼠不出现这种情况。支气管肺泡灌洗液白细胞显著增加、肺巨噬细胞浸润、肺组织中肿瘤坏死因子α和白细胞介素-6的mRNA表达增加证明了IKK2ca的诱导伴随着明显的肺部炎症。IKK2ca的肺特异性过度表达所致的这种肺部炎症增加循环TNFα和IL-6水平,脂肪TNF-α和IL-6mRNA的表达,主动脉内皮功能障碍以及全身性胰岛素抵抗。出乎意料的是,在这些小鼠中没有观察到TNF-α和IL-6mRNA的下丘脑表达和葡萄糖耐受不良的显著改变。该研究表明,肺部炎症足以诱发全身炎症,内皮功能障碍和胰岛素抵抗,但不会引起下丘脑炎症和葡萄糖耐受不良。

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    2018-04-28 baoya
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Nov 30 08:53:29 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265572, encodeId=babc2655e2f8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Thu Nov 30 08:53:24 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421123, encodeId=af01142112370, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450036, encodeId=e28d145003651, content=<a href='/topic/show?id=85eb304409c' target=_blank style='color:#2F92EE;'>#内皮功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30440, encryptionId=85eb304409c, topicName=内皮功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41d5536295, createdName=zhangxingru, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516554, encodeId=2a8c15165541c, content=<a href='/topic/show?id=3b0329699d3' target=_blank style='color:#2F92EE;'>#全身炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29699, encryptionId=3b0329699d3, topicName=全身炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f6210986148, createdName=12498dd9m14暂无昵称, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262875, encodeId=f9052628e576, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 20 17:06:32 CST 2017, time=2017-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262764, encodeId=65a3262e6499, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Nov 20 08:02:24 CST 2017, time=2017-11-20, status=1, ipAttribution=)]
    2017-11-30 往日如昨

    继续学习中谢谢

    0

  5. 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time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450036, encodeId=e28d145003651, content=<a href='/topic/show?id=85eb304409c' target=_blank style='color:#2F92EE;'>#内皮功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30440, encryptionId=85eb304409c, topicName=内皮功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41d5536295, createdName=zhangxingru, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516554, encodeId=2a8c15165541c, content=<a href='/topic/show?id=3b0329699d3' target=_blank style='color:#2F92EE;'>#全身炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29699, encryptionId=3b0329699d3, topicName=全身炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f6210986148, createdName=12498dd9m14暂无昵称, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262875, encodeId=f9052628e576, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 20 17:06:32 CST 2017, time=2017-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262764, encodeId=65a3262e6499, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Nov 20 08:02:24 CST 2017, time=2017-11-20, status=1, ipAttribution=)]
    2017-11-30 往日如昨

    学习了谢谢分享

    0

  6. 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time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450036, encodeId=e28d145003651, content=<a href='/topic/show?id=85eb304409c' target=_blank style='color:#2F92EE;'>#内皮功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30440, encryptionId=85eb304409c, topicName=内皮功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41d5536295, createdName=zhangxingru, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516554, encodeId=2a8c15165541c, content=<a href='/topic/show?id=3b0329699d3' target=_blank style='color:#2F92EE;'>#全身炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29699, encryptionId=3b0329699d3, topicName=全身炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f6210986148, createdName=12498dd9m14暂无昵称, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262875, encodeId=f9052628e576, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 20 17:06:32 CST 2017, time=2017-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262764, encodeId=65a3262e6499, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Nov 20 08:02:24 CST 2017, time=2017-11-20, status=1, ipAttribution=)]
  7. 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time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450036, encodeId=e28d145003651, content=<a href='/topic/show?id=85eb304409c' target=_blank style='color:#2F92EE;'>#内皮功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30440, encryptionId=85eb304409c, topicName=内皮功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41d5536295, createdName=zhangxingru, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516554, encodeId=2a8c15165541c, content=<a href='/topic/show?id=3b0329699d3' target=_blank style='color:#2F92EE;'>#全身炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29699, encryptionId=3b0329699d3, topicName=全身炎症)], attachment=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Nov 20 08:02:24 CST 2017, time=2017-11-20, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=2060765, encodeId=3a7f2060e6568, content=<a href='/topic/show?id=54ee3044405' target=_blank style='color:#2F92EE;'>#内皮功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30444, encryptionId=54ee3044405, topicName=内皮功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Aug 24 16:24:00 CST 2018, time=2018-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749865, encodeId=82f81e4986560, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, 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time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450036, encodeId=e28d145003651, content=<a href='/topic/show?id=85eb304409c' target=_blank style='color:#2F92EE;'>#内皮功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30440, encryptionId=85eb304409c, topicName=内皮功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41d5536295, createdName=zhangxingru, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516554, encodeId=2a8c15165541c, content=<a href='/topic/show?id=3b0329699d3' target=_blank style='color:#2F92EE;'>#全身炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29699, encryptionId=3b0329699d3, topicName=全身炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f6210986148, createdName=12498dd9m14暂无昵称, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262875, encodeId=f9052628e576, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 20 17:06:32 CST 2017, time=2017-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262764, encodeId=65a3262e6499, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Nov 20 08:02:24 CST 2017, time=2017-11-20, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=2060765, encodeId=3a7f2060e6568, content=<a href='/topic/show?id=54ee3044405' target=_blank style='color:#2F92EE;'>#内皮功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30444, encryptionId=54ee3044405, topicName=内皮功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Aug 24 16:24:00 CST 2018, time=2018-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749865, encodeId=82f81e4986560, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, 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Nov 30 08:53:29 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265572, encodeId=babc2655e2f8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Thu Nov 30 08:53:24 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421123, encodeId=af01142112370, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450036, encodeId=e28d145003651, content=<a href='/topic/show?id=85eb304409c' target=_blank style='color:#2F92EE;'>#内皮功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30440, encryptionId=85eb304409c, topicName=内皮功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41d5536295, createdName=zhangxingru, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516554, encodeId=2a8c15165541c, content=<a href='/topic/show?id=3b0329699d3' target=_blank style='color:#2F92EE;'>#全身炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29699, encryptionId=3b0329699d3, topicName=全身炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f6210986148, createdName=12498dd9m14暂无昵称, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262875, encodeId=f9052628e576, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 20 17:06:32 CST 2017, time=2017-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262764, encodeId=65a3262e6499, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Nov 20 08:02:24 CST 2017, time=2017-11-20, status=1, ipAttribution=)]
    2017-11-20 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

  10. 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time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450036, encodeId=e28d145003651, content=<a href='/topic/show?id=85eb304409c' target=_blank style='color:#2F92EE;'>#内皮功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30440, encryptionId=85eb304409c, topicName=内皮功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41d5536295, createdName=zhangxingru, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516554, encodeId=2a8c15165541c, content=<a href='/topic/show?id=3b0329699d3' target=_blank style='color:#2F92EE;'>#全身炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29699, encryptionId=3b0329699d3, topicName=全身炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f6210986148, createdName=12498dd9m14暂无昵称, createdTime=Tue Nov 21 13:24:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262875, encodeId=f9052628e576, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 20 17:06:32 CST 2017, time=2017-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262764, encodeId=65a3262e6499, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Nov 20 08:02:24 CST 2017, time=2017-11-20, status=1, ipAttribution=)]
    2017-11-20 明月清辉

    谢谢分享.学习了

    0

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