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Clinical cancer res：Degarelix联合或不联合Cy/GVAX治疗高危局限性前列腺癌的效果

2020-03-15 MedSci原创 MedSci原创

前列腺癌环磷酰胺Degarelix
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既往研究表明，雄激素剥夺治疗(ADT)可促进前列腺癌的抗肿瘤免疫。基于疫苗的方法是否能增强这一效果仍不清楚

既往研究表明，雄激素剥夺治疗(ADT)可促进前列腺癌的抗肿瘤免疫。基于疫苗的方法是否能增强这一效果仍不清楚

研究人员开展了一项新辅助的随机化研究，以量化粒细胞-巨噬细胞集落刺激因子(GM-CSF)-分泌异基因细胞疫苗联合低剂量环磷酰胺(Cy/GVAX)+地加瑞克（degarelix）或地加瑞克治对计划进行根治性前列腺切除术的高危局限性前列腺腺癌患者的免疫效果。

与未进行治疗的对照相比，Cy/GVAX+地加瑞克和单用地加瑞克均可显著增加肿瘤中的CD8+ T细胞浸润和PD-L1的表达。但CD8+ T细胞浸润伴调节性T细胞(Treg)比例增加，提示适应性Treg抵抗可能会抑制ADT的免疫原性。虽然Cy/GVAX联合地加瑞克可以适度改善PSA的进展和下一次治疗的时间，并增加PD-L1的表达，但CD8 T细胞浸润与单独使用地加瑞克无差异。基因表达谱显示，与单用地加瑞克相比，Cy/GVAX联合地加瑞克可使巨噬细胞标记物CHIT1表达上调。

本研究结果表明，无论是否联合Cy/GVAX， ADT都可在前列腺肿瘤微环境中诱导复杂的免疫反应。些数据对ADT联合免疫治疗有重要意义。特别是，该研究发现ADT可增加CD8+ T细胞和Treg的数量，支持ADT与Treg耗竭剂联合治疗前列腺癌方案的发展。

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    2020-05-09 haouestc

    #局限性#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1924046, encodeId=73821924046ef, content=<a href='/topic/show?id=61d24e655df' target=_blank style='color:#2F92EE;'>#局限性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47655, encryptionId=61d24e655df, topicName=局限性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7eeb2500172, createdName=haouestc, createdTime=Sat May 09 17:30:03 CST 2020, time=2020-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460474, encodeId=9ef614604e4b0, content=<a href='/topic/show?id=ebf74e65779' target=_blank style='color:#2F92EE;'>#局限性前列腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47657, encryptionId=ebf74e65779, topicName=局限性前列腺癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d8256335432, createdName=yang0212, createdTime=Tue Mar 17 07:30:03 CST 2020, time=2020-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507708, encodeId=2d26150e70839, content=<a href='/topic/show?id=8764484014' target=_blank style='color:#2F92EE;'>#clinical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4840, encryptionId=8764484014, topicName=clinical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ee59933733, createdName=zll0628, createdTime=Tue Mar 17 07:30:03 CST 2020, time=2020-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380542, encodeId=33603805421c, content=新冠全球大爆发，当时在中国出现时，其他国家没重视吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/kGw5jg99bxLo3JvFSwO53KRlnpeV71YF9nhR1tRQHxASyfpaQ1OYpH94z7399OIkpUHmyhLQbJunNpGOfBnjJA/132, createdBy=bdee5289307, createdName=libra2778, createdTime=Mon Mar 16 04:19:14 CST 2020, time=2020-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040680, encodeId=391c10406807e, content=前列腺癌相关研究，学习了，谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Mar 15 19:30:03 CST 2020, time=2020-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047012, encodeId=8b16104e01294, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Mar 15 19:30:03 CST 2020, time=2020-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380527, encodeId=7fd938052e0a, content=论团队, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/sL9VBZ1wX08pLbnNXBTnGAPaat7fkRukxXNMYNK4LzUWFibcvg7WRPme5Uy5mh1f5HW9qicG1etmDBGsqsrbg2yg/132, createdBy=9ce65310990, createdName=xcdnxj, createdTime=Sun Mar 15 19:14:31 CST 2020, time=2020-03-15, status=1, ipAttribution=)]
    2020-03-17 yang0212

    #局限性前列腺癌#

    0

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    2020-03-17 zll0628

    #clinical#

    0

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    2020-03-16 libra2778

    新冠全球大爆发，当时在中国出现时，其他国家没重视吗？

    0

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    2020-03-15 misszhang

    前列腺癌相关研究，学习了，谢谢梅斯

    0

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    2020-03-15 CHANGE

    疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的

    0

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    2020-03-15 xcdnxj

    论团队

    0

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