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Stroke:急性使用可卡因增加了早发性缺血性脑卒中的风险

2016-03-12 MedSci MedSci原创

虽然病例报告早就确定了使用可卡因和缺血性脑卒中(IS)之间的关联,但很少有流行病学研究阐述青壮年IS与使用可卡因的关联,通过定期的,途径和使用频率进行确定。研究人员进行了一项基于人群的病例对照研究,通过1090例患者和1154名对照来调查使用可卡因和青年人IS发病的关联。卒中病例均在15至49岁之间。采用Logistic回归分析,以评估使用可卡因和IS之间的关联,其中的IS是经过了有或没有潜在的混

虽然病例报告早就确定了使用可卡因和缺血性脑卒中(IS)之间的关联,但很少有流行病学研究阐述青壮年IS与使用可卡因的关联,通过定期的,途径和使用频率进行确定。

研究人员进行了一项基于人群的病例对照研究,通过1090例患者和1154名对照来调查使用可卡因和青年人IS发病的关联。卒中病例均在15至49岁之间。采用Logistic回归分析,以评估使用可卡因和IS之间的关联,其中的IS是经过了有或没有潜在的混杂因素进行了调整。

曾经使用可卡因与卒中发生无关,28%的病例患者和26%的对照被报告曾经使用可卡因。相反,在过去24小时内急性可卡因的使用强烈增加了卒中的风险(年龄性别,种族调整后的比值比6.4;95%置信区间,2.2-18.6)。在急性使用者中,吸烟途径调整后比值比7.9(95%置信区间,1.8-35.0),而吸入途径校正比值比为3.5(95%置信区间,0.7-16.9)。对于当前的酒精,吸烟用途,和高血压的调整后,通过任何途径急性使用可卡因比值比是5.7(95%置信区间,1.7-19.7)。26例患者在卒中发作的24小时内使用可卡因,14例被报道在卒中发生6小时内使用。

该研究的数据与急性使用可卡因和早发性IS风险存在的因果关系是一致的。

原始出处:

Cheng YC,Ryan KA,Qadwai SA,et al.Cocaine Use and Risk of Ischemic Stroke in Young Adults,Stroke,2016.3.10

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