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Int J Cancer:生活方式因素与结直肠癌风险的降低密切相关(前瞻性队列研究)

2017-10-31 MedSci MedSci原创

以往的研究表明,健康的生活方式因素与结直肠癌的发病风险降低有关。然而,很少有研究探讨这些因素的共同作用。 我国研究人员评估了联合生活方式对结直肠癌风险的影响,并评估了这些生活方式因素的人群归因风险。

以往的研究表明,健康的生活方式因素与结直肠癌的发病风险降低有关。然而,很少有研究探讨这些因素的共同作用。

我国研究人员评估了联合生活方式对结直肠癌风险的影响,并评估了这些生活方式因素的人群归因风险。

研究人员使用上海男性健康研究的数据(2002-2013年),研究人员构建了健康的生活方式指数,包含以下生活方式的因素:吸烟、饮酒、饮食、腰臀比和运动情况。研究人员采用Cox比例风险模型计算危险比(HR)和95%可信区间(CIS)。

研究发现,在中位数随访的9.28年里,研究人员在59503名男性中确诊了671名结直肠癌患者(400例结肠癌和274例直肠癌)。健康生活方式指数每增加一个与结直肠癌风险降低17%(HR = 0.83,95% CI:0.78,0.89),结肠癌风险降低10%(HR = 0.90,95% CI:0.83,0.99)和直肠癌风险降低27%(HR = 0.73,95% CI:0.66,0.82)相关。

如果队列中所有的男性都遵循这五个因素定义的生活方式,那么就能预防21%的大肠癌病例发生(PAR = 21%,95% CI:4%,36%)。

总之,生活方式因素与结直肠癌风险的降低密切相关,且对直肠癌的影响比结肠癌更为明显。

原始出处:

Zhang QL, Zhao LG,et al.The joint effects of major lifestyle factors on colorectal cancer risk among Chinese men: A prospective cohort study.Int J Cancer. 2017 Oct 21. doi: 10.1002/ijc.31126. [Epub ahead of print]

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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257660, encodeId=23dd25e66033, content=生活方式因素与结直肠癌风险的降低密切相关(前瞻性队列研究), beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Wed Nov 01 05:47:32 CST 2017, time=2017-11-01, status=1, ipAttribution=)]
    2018-02-22 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

  5. 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    2018-05-30 sjq027
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  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257660, encodeId=23dd25e66033, content=生活方式因素与结直肠癌风险的降低密切相关(前瞻性队列研究), beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Wed Nov 01 05:47:32 CST 2017, time=2017-11-01, status=1, ipAttribution=)]
    2017-11-01 天地飞扬

    谢谢分享!

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257660, encodeId=23dd25e66033, content=生活方式因素与结直肠癌风险的降低密切相关(前瞻性队列研究), beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Wed Nov 01 05:47:32 CST 2017, time=2017-11-01, status=1, ipAttribution=)]
    2017-11-01 yjs木玉

    谢谢了.学习.受教

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257660, encodeId=23dd25e66033, content=生活方式因素与结直肠癌风险的降低密切相关(前瞻性队列研究), beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Wed Nov 01 05:47:32 CST 2017, time=2017-11-01, status=1, ipAttribution=)]
    2017-11-01 ann y

    生活方式因素与结直肠癌风险的降低密切相关(前瞻性队列研究)

    0

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黏着斑激酶(FAK)是肿瘤信号的多功能调节因子,在几种肿瘤中均有表达。已有报道FAK表达可以作为局部直肠癌肿瘤反应的预测因素。其在抗血管生成中所扮演的功能角色尚不清楚。抗血管生成治疗通常用于转移性结直肠癌。ANN ONCOL近期发表了一篇文章,研究接受标准抗血管生成治疗的结直肠癌动物模型中FAK可能参与的过程。

盘点:近期关于结直肠癌研究进展精华一览

【1】Nutrition:警示!"炎症性饮食"或增加结直肠癌风险慢性炎症可造成癌症。饮食通过改变炎症生物标志物的循环水平而在调节慢性炎症中起到重要作用。2017年6月,发表在《Nutrition》的一项在加拿大纽芬兰进行的基于人群的病例对照研究调查了炎症性饮食和结直肠癌风险之间的相关性。研究总共纳入了547例CRC病例(来自于纽芬兰结直肠癌注册)和686例来自于普通人群的对照。社会人口学、用药

Gastroenterology:霍乱疫苗可降低结直肠癌患者死亡风险

Ji等研究团队最近在《Gastroenterology》发表最新研究结果,显示霍乱疫苗具有抗炎作用,可以作为免疫反应的调节器;能够减少结肠息肉在结直肠癌(CRC)小鼠模型中的发育。该团队进行了一项以人口为基础的研究,以确定在CRC诊断中,随后的霍乱疫苗(杀死霍乱弧菌O1全细胞和重组霍乱毒素B亚单位)是否会影响死亡率。

Nat Med:癌症无法治愈新解释

研究人员发现称为MIR100HG的长非编码RNA的表达增加,其含有两个也具有增加性表达的微小RNA,miR-100和miR-125b。长的非编码RNA和微RNA从基因组转录为基因,但它们不编码蛋白质。相反,这些RNA协调复杂的表观遗传过程来调节基因表达。

Onco Targets Ther:靶向Fn或可用于结直肠癌的预防及治疗

结直肠癌(CRC)是一种常见的消化系统恶性肿瘤,近期研究发现CRC的发生与肠道菌群变化密切相关。已知具核梭杆菌(Fn)为大肠癌的致病菌;然而,Fn与患者预后之间的关系研究尚少,且在晚期患者的研究也较少。因此,在这项研究中,研究人员在280个III期/ IV期CRC患者的回顾性队列中研究Fn的水平和对患者的预后意义。结果发现,肿瘤组织中Fn的水平异常高,与肿瘤浸润、淋巴结转移及远处转移有关。此外,研

ANN ONCOL:E-cadherin在转移性结直肠癌治疗中的作用

上皮间质转化(EMT)是胚胎形成过程中的重要步骤,也是细胞转移的可能机制之一。上皮间质转化过程中,上皮细胞失去功能和极性,重塑细胞骨架,细胞形态和重组基因表达发生改变。这会增加细胞活动能力,有助于发展成为侵袭性亚型。E-cadherin表达缺乏和N-cadherin水平增加被认为是EMT过程中的基础步骤。这些改变与肿瘤进展和淋巴结转移有关。ANN ONCOL近期发表了一篇文章,研究E-cadher

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