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JCLA:短暂弹性成像肝脏硬度可作为评估慢性肾病患者的非酒精性脂肪肝一个潜在的指标

2019-06-03 不详 网络

本研究旨在确定瞬态弹性成像(TE)测量的肝脏硬度对超声诊断NAFLD的慢性肾病(CKD)患者的诊断价值。 2015年10月至2017年8月,研究人员于吉林大学中日联合医院招募1439名符合初步条件的超声诊断为NAFLD的成年患者。根据排除标准,排除24例患者,最终纳入1415例患者。通过血液测试计算AST/ALT比值和FIB‐4评分,并使用TE测量肝脏硬度。 研究显示,CKD患者的TE

本研究旨在确定瞬态弹性成像(TE)测量的肝脏硬度对超声诊断NAFLD的慢性肾病(CKD)患者的诊断价值。

201510月至20178月,研究人员于吉林大学中日联合医院招募1439名符合初步条件的超声诊断为NAFLD的成年患者。根据排除标准,排除24例患者,最终纳入1415例患者。通过血液测试计算AST/ALT比值和FIB4评分,并使用TE测量肝脏硬度。

研究显示,CKD患者的TEFIB4评分、ALT/AST比值明显高于无CKD患者(P < 0.001)。肝脏硬度、FIB4评分和AST/ALT比值曲线(AUROC)下面积分别为0.694(0.6700.718)0.707(0.6820.730)0.712(0.6880.736),三种测试之间无统计学差异。此外,多变量分析确定了CKD的四个独立危险因素:年龄、糖尿病、血清尿酸和肝脏僵硬。此外,在logistic回归模型中,这四个自变量一起识别CKD的表现为0.834 (AUROC;95%CI: 0.8140.853),且显示出比单一应用肝僵硬更高的诊断性能。

因此,本研究表明TE评估的肝脏硬度是超声诊断NAFLD患者CKD的潜在指标。此外,一个四变量模型(肝脏硬度、年龄、血清尿酸和糖尿病)可以作为一个有用的工具,用于识别NAFLD患者中CKD高危人群。

原始出处:

Shaoyou Qin, Song Wang ,Liver stiffness assessed by transient elastography as a potential indicator of chronic kidney disease in patients with nonalcoholic fatty liver disease

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非酒精性脂肪性肝病引起几种不同严重程度的肝功能异常,其特征是肝细胞中脂肪的积累,但不是由高酒精摄入引起的。这种疾病是发达国家最常见的疾病之一,全世界约25%的人口中受到影响。生物医学研究所(IRB Barcelona)的一个研究小组已经确定了一个可以对抗这种疾病的因素,即蛋白质Mitofusin 2。

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