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Pediatrics:儿童癫痫及共患病:全国性注册研究

2016-08-06 MedSci MedSci原创

患有癫痫的儿童在诊断之前,诊断同时及之后合并其他疾病的风险增加。评估风险的方法各异,很少有研究是以人群为基础的,也很少有研究提供了共患病的全面评估。我们使用全国性注册数据描述儿童在诊断癫痫之前和之后的医疗、神经病学、发育和精神状况。 数据来源挪威患者注册数据库,这是一个官方的基于国际疾病分类,来源挪威所有政府资助的特殊医疗机构(门诊咨询和住院)的第10次修正诊断。我们在2008年到2013年

患有癫痫的儿童在诊断之前,诊断同时及之后合并其他疾病的风险增加。评估风险的方法各异,很少有研究是以人群为基础的,也很少有研究提供了共患病的全面评估。我们使用全国性注册数据描述儿童在诊断癫痫之前和之后的医疗、神经病学、发育和精神状况。

数据来源挪威患者注册数据库,这是一个官方的基于国际疾病分类,来源挪威所有政府资助的特殊医疗机构(门诊咨询和住院)的第10次修正诊断。我们在2008年到2013年期间,收集了1996年到2013年所有在挪威出生的儿童的数据(随访结束时年龄为1-17岁)。比较癫痫儿童及普通儿童,调整性别和年龄。同时也比较患有复杂癫痫(如,癫痫合并其他神经系统疾病和/或发育障碍)的儿童与非复杂癫痫儿童。

结果:研究包含1125161名儿童。6635 (0.6%) 名儿童患有癫痫。将近80%患有癫痫的儿童合并≥1个共患病。所有类型的疾病在癫痫儿童中都更常见,其他的内科疾病占55%,神经系统疾病41%,发育/精神障碍43%。复杂癫痫儿童有最高比例的所有类型的共患病,但非复杂癫痫儿童的内科和精神科共患病也有很大比例。

结论:癫痫儿童的共患病整体频率较高,包括假定为非复杂癫痫的儿童。

原始出处:

Aaberg KM1, Bakken IJ2, Lossius MI3, et  al,Comorbidity and Childhood Epilepsy: A Nationwide Registry Study.Pediatrics. 2016 Aug 1. pii: e20160921. [Epub ahead of print]


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time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556735, encodeId=55bd1556e35dd, content=<a href='/topic/show?id=e4016495635' target=_blank style='color:#2F92EE;'>#注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Mon Aug 08 13:37:00 CST 2016, time=2016-08-08, status=1, ipAttribution=)]
    2017-06-22 mjldent
  2. 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    2016-09-11 feather89
  3. 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time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556735, encodeId=55bd1556e35dd, content=<a href='/topic/show?id=e4016495635' target=_blank style='color:#2F92EE;'>#注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Mon Aug 08 13:37:00 CST 2016, time=2016-08-08, status=1, ipAttribution=)]
    2016-09-04 hbwxf
  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Oct 09 13:26:48 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=113624, encodeId=821d11362494, content=好文章,赞一个!值得深入学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Sep 08 12:09:00 CST 2016, time=2016-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110112, encodeId=4efa11011200, 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  5. 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  6. 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content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:56:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511155, encodeId=62251511155c4, content=<a href='/topic/show?id=815d2836e83' target=_blank style='color:#2F92EE;'>#儿童癫痫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28367, encryptionId=815d2836e83, topicName=儿童癫痫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=506410296183, createdName=chshh80, createdTime=Mon Aug 08 13:37:00 CST 2016, time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556735, encodeId=55bd1556e35dd, content=<a href='/topic/show?id=e4016495635' target=_blank style='color:#2F92EE;'>#注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Mon Aug 08 13:37:00 CST 2016, time=2016-08-08, status=1, ipAttribution=)]
    2016-10-09 ylzr123

    好文,从这里学习了好多新知识,新信息。赞了!

    0

  7. 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content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:56:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511155, encodeId=62251511155c4, content=<a href='/topic/show?id=815d2836e83' target=_blank style='color:#2F92EE;'>#儿童癫痫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28367, encryptionId=815d2836e83, topicName=儿童癫痫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=506410296183, createdName=chshh80, createdTime=Mon Aug 08 13:37:00 CST 2016, time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556735, encodeId=55bd1556e35dd, content=<a href='/topic/show?id=e4016495635' target=_blank style='color:#2F92EE;'>#注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Mon Aug 08 13:37:00 CST 2016, time=2016-08-08, status=1, ipAttribution=)]
    2016-09-08 ylzr123

    好文章,赞一个!值得深入学习。

    0

  8. 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content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:56:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511155, encodeId=62251511155c4, content=<a href='/topic/show?id=815d2836e83' target=_blank style='color:#2F92EE;'>#儿童癫痫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28367, encryptionId=815d2836e83, topicName=儿童癫痫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=506410296183, createdName=chshh80, createdTime=Mon Aug 08 13:37:00 CST 2016, time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556735, encodeId=55bd1556e35dd, content=<a href='/topic/show?id=e4016495635' target=_blank style='color:#2F92EE;'>#注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Mon Aug 08 13:37:00 CST 2016, time=2016-08-08, status=1, ipAttribution=)]
    2016-09-03 李东泽

    很好,不错,以后会多学习

    0

  9. 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  10. 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time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556735, encodeId=55bd1556e35dd, content=<a href='/topic/show?id=e4016495635' target=_blank style='color:#2F92EE;'>#注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Mon Aug 08 13:37:00 CST 2016, time=2016-08-08, status=1, ipAttribution=)]
    2016-08-08 zhyy93

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