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Stroke:妊娠期脑卒中和脑血管疾病

2018-11-21 xing.T MedSci原创

由此可见,妊娠期卒中发病率上升,特别是产后期,其与妊娠期高血压疾病(尤其是先兆子痫)密切相关,这表明分娩后仍需要对重症高血压患者进行密切随访。

尽管死亡和残疾的相关负担很高,但很少有研究评估过妊娠期间卒中流行病学指标。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,在这项研究中,研究人员的目的是量化妊娠期卒中和脑血管疾病相关的发病率、时间趋势、危险因素和病死率。

研究人员从加拿大卫生信息研究所收集了2003年至2016年期间加拿大(魁北克除外)所有在分娩后42天内的产前、围产期和产后住院和再入院患者,并使用Logistic回归评估了卒中的时间趋势和量化了相关的危险因素。

在3907262次分娩中研究人员确定了524例卒中病例(每10万人中有13.4例)。大多数病例为出血性卒中(307例,58.6%),多数发生于产后期(270例,51.5%)。病死率为7.4%。卒中发病率从2003年至2014年间的10万人中10.8人增加到2015年至2016年间的每10万人中16.6人(P=0.002)。卒中的危险因素包括孕妇年龄较大(年龄≥40岁;调整后的比值比[AOR]为1.7; 95%CI为1.1-2.6)、先兆子痫(AOR为7.1; 95%CI为5.3-9.6)、子痫(AOR为 65.9; 95%CI为43.6-99.6)、孕妇先天性心脏病(AOR为38.1; 95%CI为22.1-65.8)、结缔组织疾病(AOR为12.6; 95%CI为6.1-26.9)、败血症(AOR为7.6; 95%CI为3.6-16.2)、严重的产后出血(AOR为4.7; 95%CI为2.8-8.0)和血栓形成倾向(AOR为4.2; 95%CI为1.5-12.1)。

由此可见,妊娠期卒中发病率上升,特别是产后期,其与妊娠期高血压疾病(尤其是先兆子痫)密切相关,这表明分娩后仍需要对重症高血压患者进行密切随访。

原始出处:

Shiliang Liu,et al.Stroke and Cerebrovascular Disease in Pregnancy Incidence, Temporal Trends, and Risk Factors.Stroke. 2018.https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.022751

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    2018-11-23 wjcjjian
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    2018-11-21 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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