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J Pediatr:PCR检测新生儿单纯疱疹病毒感染

2014-12-07 MedSci MedSci原创译

J Pediatr近日发布的一项研究表明,新生儿单纯疱疹病毒(herpes simplex virus,HSV)疾病的临床表现和死亡率有关,但是与神经系疾病没有相关性为了评估单疱病毒qPCR检测判断新生儿HSV疾病预后的效果,西雅图儿童研究机构儿童感染科的Ann J. Melvin医生及其同事对1993-2012年在西雅图儿童医院治疗的HSV感染新生儿的临床和病毒数据进行研究。研究共纳入了63名婴

J Pediatr近日发布的一项研究表明,新生儿单纯疱疹病毒(herpes simplex virus,HSV)疾病的临床表现和死亡率有关,但是与神经系疾病没有相关性

为了评估单疱病毒qPCR检测判断新生儿HSV疾病预后的效果,西雅图儿童研究机构儿童感染科的Ann J. Melvin医生及其同事对1993-2012年在西雅图儿童医院治疗的HSV感染新生儿的临床和病毒数据进行研究。

研究共纳入了63名婴儿的数据,其中有47名用PCR检测血浆HSV,56名用PCR检测脑脊液HSV,而40名既有血浆也有脑脊液HSV的PCR检测结果。这63名婴儿中有26名患有皮肤眼口(skin-eye-mouth,SEM)感染,18名患有中枢神经系统感染(central nervous system,CNS),19名患有弥散性( disseminated,DIS)疾病。

结果发现,SEM婴儿中血清HSV的PCR阳性率为78%,CNS婴儿中有64%的阳性率,DIS疾病的婴儿的阳性率为100%。SEM婴儿的平均血清病毒载量为2.8lg10拷贝/mL,CNS婴儿的平均血清病毒载量为2.2lg10拷贝/mL,DIS婴儿的平均血清病毒载量为7.2lg10拷贝/mL。与存活下来的婴儿HSV3.8lg10拷贝/mL(在0.0-8.6范围内)相比,因HSV感染死亡的婴儿其HSV水平更高,为8.1lg10拷贝/mL(在7.7-8.6范围内),P=0.001。

然而,脑脊液和血清中HSV的DNA的含量与神经系统疾病没有相关性。大剂量阿昔洛韦治疗时,血清动态HSV清除率呈现出单相指数衰减,病毒的平均半衰期为1.26天(在0.8-1.51范围内)。

研究表明,HSV含量与新生儿HSV疾病的临床表现和死亡率有关,但是与神经系疾病没有相关性。

原始出处:

Melvin, A.J., et al., Plasma and Cerebrospinal Fluid Herpes Simplex Virus Levels at Diagnosis and Outcome of Neonatal Infection. The Journal of Pediatrics.

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    2015-02-24 feather89
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    2014-12-09 Tommy1950
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    2014-12-09 howi

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