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PLoS One:急性缺血性卒中患者,入院体温与三天后闭塞血管再通没有关系

2015-10-29 phylis 译 MedSci原创

背景:闭塞颅内动脉再通受到温度依赖酶的影响,包括阿替普酶。研究者评估入院体温和再通之间的关系。方法:共有13个中心278名急性缺血性卒中症状开始9个小时内的患者,研究者对其进行入院CT血管造影检查。研究者计算入院体温每升高1摄氏度和三天内再通的关系。结果:80%闭塞动脉发生再通。校正年龄,入院NIHSS分数及阿替普酶治疗后,入院体温和三天再通没有关系()。应用阿替普酶治疗与未治疗的患者结果一致。结

背景:闭塞颅内动脉再通受到温度依赖酶的影响,包括阿替普酶。研究者评估入院体温和再通之间的关系。

方法:共有13个中心278名急性缺血性卒中症状开始9个小时内的患者,研究者对其进行入院CT血管造影检查。研究者计算入院体温每升高1摄氏度和三天内再通的关系。

结果:80%闭塞动脉发生再通。校正年龄、入院NIHSS分数及阿替普酶治疗后,入院体温和三天再通没有关系(每0.1°摄氏度调整后的优势比,0.99;95%置信区间,0.94 - -1.05,p = 0.70)。应用阿替普酶治疗与未治疗的患者结果一致。

结论:研究结果表明:不管是否应用阿替普酶治疗,急性缺血性卒中患者入院体温和闭塞颅内动脉三天后再通没有关系。

原文出处:

Geurts M, van der Worp HB, Horsch AD,et al. No Relation between Body Temperature and Arterial Recanalization at Three Days in Patients with Acute Ischaemic Stroke. PLoS One. 2015,Oct 16


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