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Stroke:血清半乳凝素-3与急性缺血性脑卒中患者不良预后之间的关系!

2017-12-11 xing.T MedSci原创

由此可见,高水平的血清半乳凝素-3与卒中发病后死亡或严重残疾的风险增加独立相关,这表明半乳凝素-3可能在缺血性脑卒中患者预后不良具有预测价值。

半乳凝素-3升高已与动脉粥样硬化和心力衰竭患者不良结局相关。然而,目前尚不清楚半乳凝素-3是否对缺血性脑卒中不良预后具有影响。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,该研究的目的是评估急性缺血性脑卒中患者半乳凝素-3水平与不良预后之间的相关性。

研究人员测量了3082例急性缺血性脑卒中患者血清中半乳凝素-3的水平。该研究的主要的结局为卒中后3个月内死亡或严重残疾(改良Rankin量表评分≥3)的复合结局。

与半乳凝素-3水平最低组相比,最高四分位数半乳凝素-3水平患者多变量调整后复合结局的比值比(95%可信区间)为1.55(1.15-2.09),对于死亡为2.10(0.89-4.95),对于严重残疾为1.43(1.05-1.93)。将半乳凝素-3加入到传统危险因素中可以显著改善对缺血性脑卒中患者死亡的复合结局或严重残疾的预测能力(净重分类指数为18.9%;P<0.001;综合判别的改进为0.4%;P=0.001)。

由此可见,高水平的血清半乳凝素-3与卒中发病后死亡或严重残疾的风险增加独立相关,这表明半乳凝素-3可能在缺血性脑卒中患者预后不良具有预测价值。

原始出处:


Aili Wang,et al. Serum Galectin-3 and Poor Outcomes Among Patients With Acute Ischemic Stroke.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.117.019084

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