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Obstet Gynecol:严重冠状病毒感染的妊娠结局

2020-06-16 MedSci原创 MedSci原创

妊娠期间SARS-CoV、MERS-CoV和SAR-CoV-2感染的病例报告数据有限,但它们可能会指导早期公共卫生行动和COVID-19的临床决策。

为充分了解当前的2019冠状病毒疾病(COVID-19)爆发,近日,妇产科权威杂志Obstetrics and Gynecology上发表了一篇研究文章,研究人员对报道在妊娠期间感染中东呼吸综合征冠状病毒(MERS-CoV)、严重急性呼吸综合征冠状病毒(SARS-CoV)和严重急性呼吸道综合征冠状病毒2(SARS-CoV-2)和引起COVID-19病毒病例的研究进行了系统评价,旨在概述临床表现、病程以及妊娠和新生儿结局。

研究人员检索了MEDLINE和ClinicalTrials.gov,检索时间从数据库成立到2020年4月23日。研究人员纳入了报道感染MERS-CoV、SARS-CoV和SARS-CoV-2孕妇的文献。从纳入的文章中摘录了病程、严重疾病的指标、孕产妇健康结局和妊娠结局。

研究人员确定了1328篇独特的文献,其中1253篇文献通过标题和摘要审阅被排除。研究人员完成了75篇文献的全文检索,其中29篇文章通过全文检索后被排除。在报告病例水平数据的46项文献中,有8项描述了12例MERS-CoV感染病例,有7项描述了17例SARS-CoV感染病例,还有31项描述了98例SARS-CoV-2感染病例。临床表现和病程从无症状到严重致命疾病不等,与一般患者相似。在妊娠期间感染MERS-CoV、SARS-CoV或SARS-CoV-2感染孕妇中报道了严重发病和死亡情况,以及不良的妊娠结局,包括流产、早产和母婴垂直传播。

由此可见,必须了解孕妇是否可能因严重的冠状病毒感染而产生不良的母婴结局。妊娠期间SARS-CoV、MERS-CoV和SAR-CoV-2感染的病例报告数据有限,但它们可能会指导早期公共卫生行动和COVID-19的临床决策。需要捕获关键数据才能更好地确定这种感染如何影响孕妇和新生儿。

原始出处:

Galang, Romeo R.et al.Severe Coronavirus Infections in Pregnancy A Systematic Review.Obstetrics & Gynecology.2020.https://journals.lww.com/greenjournal/Abstract/9000/Severe_Coronavirus_Infections_in_Pregnancy__A.97313.aspx

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