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Circulation:儿童感染病毒增加了动脉缺血性中风的风险

2016-01-30 MedSci MedSci原创

流行病学研究表明,儿童期感染,包括水痘带状疱疹病毒(VZV),增加了动脉缺血性中风(AIS)的风险。在一些报道的案例中其他疱疹病毒已与儿童AIS有关。研究人员试图确定疱疹病毒感染,这种可潜在治疗的,是否增加儿童期的AIS的危险。研究人员招募了326例AIS的集中确诊病例,和115名无中风对照的创伤患者(年龄29天,18岁),急性血样(后中风/创伤≤3周);当病例有康复样品(7-28天后)时数据是可

流行病学研究表明,儿童期感染,包括水痘带状疱疹病毒(VZV),增加了儿童动脉缺血性中风(AIS)的风险。在一些报道的案例中其他疱疹病毒已与儿童AIS有关。研究人员试图确定疱疹病毒感染,这种可潜在治疗的,是否增加儿童期的AIS的危险。

研究人员招募了326例AIS的集中确诊病例,和115名无中风对照的创伤患者(年龄29天,18岁),急性血样(后中风/创伤≤3周);当病例有康复样品(7-28天后)时数据是可行的。样品通过商业ELISA试剂盒的IgM/IgG抗体单纯疱疹病毒(HSV)1和2,巨细胞病毒(CMV),EB病毒(EBV)和水痘带状疱疹病毒(VZV)进行测试。一种算法将过去的先验的分类血清学证据和急性疱疹病毒感染作为二分变量。先验分类血清学证据。病例的中位数(四分)年龄为7.7(3.1-14.3)岁,对照组为10.7(6.9-13.2)岁(P=0.03)。既往感染的血清学证据并不能区分病例和对照组之间的差异。然而,急性疱疹病毒感染的血清学证据增加了儿童期患AIS的两倍的可能性,即使在调整了年龄,种族和社会经济地位后(OR 2.2;95%置信区间,1.2-4.0;P=0.007)。在187例急性期和恢复期血样中,85例(45%)显示出急性疱疹病毒感染,HSV-1最为常见。大多数感染是无症状的。

疱疹病毒是童年AIS的触发,即使是亚临床感染。如果进一步的研究证实该因果关系,抗病毒药物像阿昔洛韦可预防卒中复发。

原始出处:

Elkind MS,Hills NK,Glaser CA,et al.Herpesvirus Infections and Childhood Arterial Ischemic Strok,Circulation,2016.1.28

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    2016-02-01 xugc
  4. [GetPortalCommentsPageByObjectIdResponse(id=1892728, encodeId=95061892e28ea, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Jul 17 06:11:00 CST 2016, time=2016-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500592, encodeId=7473150059234, content=<a href='/topic/show?id=a1d3e93536b' target=_blank style='color:#2F92EE;'>#缺血性中风#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79353, encryptionId=a1d3e93536b, topicName=缺血性中风)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c54f9440276, createdName=hywen7329, createdTime=Mon Feb 01 02:11:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604313, encodeId=7cf4160431372, content=<a href='/topic/show?id=71b95335396' target=_blank style='color:#2F92EE;'>#感染病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53353, encryptionId=71b95335396, topicName=感染病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=337119178396, createdName=xugc, createdTime=Mon Feb 01 02:11:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62386, encodeId=2d9d62386cc, content=这个值得重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63801659180, createdName=encyclopediat, createdTime=Sun Jan 31 20:53:00 CST 2016, time=2016-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62384, encodeId=3cc86238410, content=哪类病毒, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sun Jan 31 20:18:00 CST 2016, time=2016-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62313, encodeId=d79362313cc, content=设计得不, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9b71604602, createdName=yushouqiang, createdTime=Sun Jan 31 07:45:00 CST 2016, time=2016-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62314, encodeId=23416231447, content=不严谨, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9b71604602, createdName=yushouqiang, createdTime=Sun Jan 31 07:45:00 CST 2016, time=2016-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62281, encodeId=c2fc6228167, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Sat Jan 30 22:26:00 CST 2016, time=2016-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62258, encodeId=eaa76225862, content=重視, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Jan 30 18:38:00 CST 2016, time=2016-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62257, encodeId=28496225e04, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Jan 30 18:37:00 CST 2016, time=2016-01-30, status=1, ipAttribution=)]
    2016-01-31 encyclopediat

    这个值得重视

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1892728, encodeId=95061892e28ea, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Jul 17 06:11:00 CST 2016, time=2016-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500592, encodeId=7473150059234, content=<a href='/topic/show?id=a1d3e93536b' target=_blank style='color:#2F92EE;'>#缺血性中风#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79353, encryptionId=a1d3e93536b, topicName=缺血性中风)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c54f9440276, createdName=hywen7329, createdTime=Mon Feb 01 02:11:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604313, encodeId=7cf4160431372, content=<a href='/topic/show?id=71b95335396' target=_blank style='color:#2F92EE;'>#感染病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53353, encryptionId=71b95335396, topicName=感染病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=337119178396, createdName=xugc, createdTime=Mon Feb 01 02:11:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62386, encodeId=2d9d62386cc, content=这个值得重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63801659180, createdName=encyclopediat, createdTime=Sun Jan 31 20:53:00 CST 2016, time=2016-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62384, encodeId=3cc86238410, content=哪类病毒, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sun Jan 31 20:18:00 CST 2016, time=2016-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62313, encodeId=d79362313cc, content=设计得不, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9b71604602, createdName=yushouqiang, createdTime=Sun Jan 31 07:45:00 CST 2016, time=2016-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62314, encodeId=23416231447, content=不严谨, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9b71604602, createdName=yushouqiang, createdTime=Sun Jan 31 07:45:00 CST 2016, time=2016-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62281, encodeId=c2fc6228167, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Sat Jan 30 22:26:00 CST 2016, time=2016-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62258, encodeId=eaa76225862, content=重視, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Jan 30 18:38:00 CST 2016, time=2016-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62257, encodeId=28496225e04, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Jan 30 18:37:00 CST 2016, time=2016-01-30, status=1, ipAttribution=)]
    2016-01-31 1de3b290m83(暂无匿称)

    哪类病毒

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1892728, encodeId=95061892e28ea, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Jul 17 06:11:00 CST 2016, time=2016-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500592, encodeId=7473150059234, content=<a href='/topic/show?id=a1d3e93536b' target=_blank style='color:#2F92EE;'>#缺血性中风#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79353, encryptionId=a1d3e93536b, topicName=缺血性中风)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c54f9440276, createdName=hywen7329, createdTime=Mon Feb 01 02:11:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604313, encodeId=7cf4160431372, content=<a href='/topic/show?id=71b95335396' target=_blank style='color:#2F92EE;'>#感染病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53353, encryptionId=71b95335396, topicName=感染病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=337119178396, createdName=xugc, createdTime=Mon Feb 01 02:11:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62386, encodeId=2d9d62386cc, content=这个值得重视, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63801659180, createdName=encyclopediat, createdTime=Sun Jan 31 20:53:00 CST 2016, time=2016-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62384, encodeId=3cc86238410, content=哪类病毒, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sun Jan 31 20:18:00 CST 2016, time=2016-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62313, encodeId=d79362313cc, content=设计得不, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9b71604602, createdName=yushouqiang, createdTime=Sun Jan 31 07:45:00 CST 2016, time=2016-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62314, encodeId=23416231447, content=不严谨, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9b71604602, createdName=yushouqiang, createdTime=Sun Jan 31 07:45:00 CST 2016, time=2016-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62281, encodeId=c2fc6228167, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Sat Jan 30 22:26:00 CST 2016, time=2016-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62258, encodeId=eaa76225862, content=重視, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Jan 30 18:38:00 CST 2016, time=2016-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62257, encodeId=28496225e04, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sat Jan 30 18:37:00 CST 2016, time=2016-01-30, status=1, ipAttribution=)]
    2016-01-31 yushouqiang

    设计得不

    0

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    2016-01-31 yushouqiang

    不严谨

    0

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    2016-01-30 李继凯

    收藏

    0

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    2016-01-30 忠诚向上

    重視

    0

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    2016-01-30 忠诚向上

    好好学习

    0

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大多数父母的教育方式多是凭借经验和直觉,相对缺少一些科学依据。近日美国的《赫芬顿邮报》官网盘点了2015年度10个最有趣的健康研究,或许能给家长们提供一些帮助。 1、阅读改变儿童的大脑 众所周知,阅读对儿童大有裨益。但2015年终于有一项科学研究的结果证明了这个结论。 研究人员通过对3-5岁儿童的MRI(核磁)影像资料进行分析,阅读有助于激发学龄前儿童想象和理解、叙事

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