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阿尔茨海默病患者其大脑的尾状核增大

2017-08-04 MedSci MedSci原创

最近发表的一项研究中使用自动MRI体积测量方法(NeuroQuant®)出人意料地表现出较大的尾状核体积治疗阿尔茨海默病(AD)与主观认知功能障碍和轻度患者(SCI和MCI)。本研究的目的是探讨这一发现。材料与方法尾状核和海马体积的测定(均表现为颅内容积的比值)在257例SCI和MCI根据Winblad标准和广告根据ICD-10诊断标准。人口统计数据,认知的措施,和apoE基因ɛ4情况的收集。结果

最近发表的一项研究中使用自动MRI体积测量方法(NeuroQuant®)出人意料地表现出较大的尾状核体积治疗阿尔茨海默病(AD)与主观认知功能障碍和轻度患者(SCI和MCI)。本研究的目的是探讨这一发现。
材料与方法
尾状核和海马体积的测定(均表现为颅内容积的比值)在257例SCI和MCI根据Winblad标准和广告根据ICD-10诊断标准。人口统计数据,认知的措施,和apoE基因ɛ4情况的收集。
结果
与非痴呆患者(SCI和MCI)相比,AD患者年龄较大,女性多于女性,尾状核体积大,海马体积小(p<001)。在多元线性回归分析中,年龄和女性的性别与尾状核体积较大有关,但无论是诊断还是记忆功能都没有。年龄、性别、记忆功能与海马体积有关,年龄和记忆功能与尾核/海马比值相关。
结论
ad患者的尾状核体积较大,部分原因是年龄较大和女性。这些结果进一步的上下文中讨论(1)尾状核可能作为一个临时的补偿机制;(2)这个大脑区域的自动测量方法的性能;和(3)的病理改变。需要进一步研究,以充分了解尾状核在AD.的作用。

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    2017-11-08 一闲
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