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PLOS One:女性多生孩子可延缓衰老

2016-01-09 sunshine MedSci原创

虽然做母亲是一个非常有价值的经历,但是大部分母亲并不认为不眠之夜和发脾气可有利于延缓衰老。然而,据发表于PLoS ONE的一项新的研究发现表明,女性生育的孩子越多,衰老的速度越慢。

虽然做母亲是一个非常有价值的经历,但是大部分母亲并不认为不眠之夜和发脾气可有利于延缓衰老。然而,据发表于PLoS ONE的一项新的研究发现表明,女性生育的孩子越多,衰老的速度越慢。

研究人员在文中揭示,孩子多的女性的端粒较孩子少的女性更长。端粒是每条DNA链末端的"帽子"结构,可保护我们的染色体免于损伤。

细胞每复制一次,端粒就会变得更短。最后端粒变得很短以至于无法保护染色体,从而使得染色体容易受到伤害,这反过来又会导致细胞老化、停止运作。

既往动物研究支持了“生活史理论”的正确性,表明较高的繁殖行为与较快的生物老化有关。但是,最新研究中,Pablo Nepomnaschy和CindyBarha则反驳了这个理论。

每多生育一个孩子便可增加一些端粒的长度

研究人员共纳入了75名喀克其奎玛雅女性,评估2000-2013年之间研究对象所生育孩子的数目。

在这个为期13年的研究初始阶段,研究人员根据研究对象的唾液样本来测量这些女性的端粒长度。研究结束时,再次测量这些女性的端粒长度,但是这次是通过颊拭子。

结果发现,在13年的研究过程中,生育较多存活后代的女性的端粒较生育较少存活后代的女性端粒长。而且每多生育一个孩子,端粒增长0.059个端粒单位。

校正所有研究对象的混杂因素后仍可得到这样的结果,校正的混杂因素包括女性的年龄,生育第一胎时的年龄, 2013年时这些女性的年龄,生活习惯和家庭收入。
在评论其研究发现时,研究人员说道:

“我们的分析表明,在13年的观察研究期间,后代数量的增加可减慢端粒缩短的速度,这表明,在我们的研究对象中,生育更多的孩子可能会减慢细胞衰老的速度。”

怀孕期间雌激素分泌增加或可用于解释这些研究发现

Nepomnaschy教授推测,女性怀孕期间雌激素分泌增加或是该研究结果出现的原因。”他解释道,“雌激素可像一种有效抗氧化剂一样发挥作用,可保护细胞对抗端粒缩短。”

此外,Nepomnaschy教授说道,社会环境可能可能也发挥了一些作用,他们注意到,参与此项研究的女性中,生育较多孩子的女性从家庭和朋友处获得了更多的社会支持。

Nepomnaschy教授还补充道:“更大的支持可增加可分配给组织支持的代谢能量,从而延缓衰老的过程”。

最后,研究小组总结道,未来的研究应探究不同种族以及不同社会背景之间女性的生殖频率和生物老化之间的关联。

原始出处:

Honor Whiteman. Having more children could slow aging. MNT, 8 January 2016.

Number of children and telomere length in women: A prospective, longitudinal evaluation, Pablo Nepomnaschy, Cindy Barha et al., PLOS One, doi: 10.1371/journal.pone.0146424, published online 5 January 2016.

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    2016-01-12 xyfg98

    这真的?

    0

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    2016-01-12 xyfg98

    二胎可以有啊

    0

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    2016-01-11 不着调的小师兄

    二胎来得还真是时候

    0

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    2016-01-11 xiaotaiyang1

    推动二胎了

    0

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