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J Periodontol:牙周炎与肝病的发生也有关联?!

2016-09-28 MedSci MedSci原创

牙周炎引起的损害不仅影响牙周组织,还可加重多种疾病的严重程度,例如:类风湿性关节炎,糖尿病和肝脏疾病。本研究旨在探讨诱发性牙周炎及其诱导的全身效应对肝脏造成的损害之间的关联。 将20只大鼠分为对照组和牙周炎组。检测的指标包括牙周组织方面的牙龈出血指数(GBI),牙周探诊深度(PPD),过氧化物酶(MPO)活性,牙槽骨丧失(ABL);牙龈组织和肝脏的组织病理学检查;肝细胞中神经/胶质抗原2表达

牙周炎引起的损害不仅影响牙周组织,还可加重多种疾病的严重程度,例如:类风湿性关节炎,糖尿病和肝脏疾病。本研究旨在探讨诱发性牙周炎及其诱导的全身效应对肝脏造成的损害之间的关联。


将20只大鼠分为对照组和牙周炎组。检测的指标包括牙周组织方面的牙龈出血指数(GBI),牙周探诊深度(PPD),过氧化物酶(MPO)活性,牙槽骨丧失(ABL);牙龈组织和肝脏的组织病理学检查;肝细胞中神经/胶质抗原2表达阳性细胞的免疫组织化学,肝脏中还原型谷胱甘肽和丙二醛浓度,血清中丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST)。

GBI, PPD, MPO, ABLs和组织病理学检查证实牙周炎的发展。与对照组相比,牙周炎组小泡性脂肪变性显著增加伴随 NG2+ 周细胞显著减少。牙周炎组肝脏GSH显著降低,MDA升高。

总而言之,该研究结果发现了诱发性牙周炎与肝组织改变之间的关联,如小泡性脂肪变性,这可能是由氧化应激和脂质过氧化物增加引起的。表明,在大鼠中周细胞的减少与结扎诱发的牙周炎性肝脏疾病相关。

原始出处:

Vasconcelos DF, et al., Decrease of Pericytes is Associated With Ligature-Induced Periodontitis Liver Disease in Rats. J Periodontol. 2016 Sep 26:1-14.

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    2017-05-04 feather89
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    2016-10-12 zhixue

    牙周炎真的应该被重视起来!

    0

  3. 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    2016-10-11 1e10c84am36(暂无匿称)

    好文章,受益

    0

  4. 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  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:34:22 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
    2016-09-28 doctorJiangchao

    继续关注

    0

  6. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:34:22 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
    2016-09-28 doctorJiangchao

    继续学习

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Sep 28 21:15:59 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137315, encodeId=021413e3151a, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Sep 28 20:46:31 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137289, encodeId=af8313e289ad, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:34:22 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
    2016-09-28 风中野草

    学习了,赞一个

    0

  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:34:22 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
    2016-09-28 明月清辉

    就是这些奇思妙想才真正推动了医学的进步,为人类造福。

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Sep 28 21:15:59 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137315, encodeId=021413e3151a, content=学习了,赞一个!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Wed Sep 28 20:46:31 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137289, encodeId=af8313e289ad, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:34:22 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
    2016-09-28 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!!

    0

  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:34:22 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
    2016-09-28 知难而进

    继续关注!

    0

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