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CLIN CANCER RES：抑制EphB4-ephrin-B信号可以增强头颈部肿瘤对西妥昔单抗-放疗的治疗反应

2018-09-29 MedSci MedSci原创

头颈部肿瘤EphB4-ephrin-B治疗反应
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低反应率和治疗耐药成为西妥昔单抗和放疗（RT）等治疗策略取得临床成功的主要阻碍。CLIN CANCER RES近期发表了一篇文章，研究EphB4-ephrin-B2原癌基因信号在头颈部肿瘤的EGFR抑制和放疗耐药中的作用。

低反应率和治疗耐药成为西妥昔单抗和放疗（RT）等治疗策略取得临床成功的主要阻碍。CLIN CANCER RES近期发表了一篇文章，研究EphB4-ephrin-B2原癌基因信号在头颈部肿瘤的EGFR抑制和放疗耐药中的作用。

作者使用患者来源的头颈部鳞状细胞癌（HNSCC）异种移植（PDX）模型和HNSCC细胞系来验证其假设。对肿瘤组织进行PhosphoRTK和WB检测以研究EphB4-ephrin-B2的变化。分别对PDX肿瘤和HNSCC细胞系进行mRNA测序和芯片数据分析，以明确与肿瘤细胞生长，增殖和存活有关的基因表达的差异。通过MTT实验研究下调EphB4 / ephrin-B2表达对HNSCC细胞生长的影响。研究结果表明，接受标准放化疗治疗的局部晚期HNSCC患者治疗失败后EphB4和ephrin-B2水平升高。EphB4-ephrin-B2抑制可以显着增强对西妥昔单抗和RT的治疗反应，延长小鼠的生存。肿瘤生长的抑制伴随着促增殖分子水平的下调和细胞凋亡的增加。

文章最后认为，采用合理的药物组合可以提高治疗效果。阻断EphB4-ephrin-B可以增强HNSCC对西妥昔单抗-放疗的治疗反应，可能会对这些患者产生临床获益。

原始出处：

Shilpa Bhatia, Jaspreet Sharma,et al. Inhibition of EphB4–Ephrin-B2 Signaling Enhances Response to Cetuximab–Radiation Therapy in Head and Neck Cancers.CLIN CANCER RES.September 2018 doi: 10.1158/1078-0432.CCR-18-0327

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    2019-01-24 chengjn

    #西妥昔#

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    2018-10-01 wshxjq

    #头颈部#

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    2018-10-01 木头人519

    #颈部#

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    2018-09-29 123faa6dm71暂无昵称

    放疗技术的改进 现如今放化疗耐药是限制提高局控率降低远转的主要难题 这个基因的发现将有助于耐药机制的研究

    0

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    2018-09-29 xuexin53

    学习

    0

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