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Ann Rheum Dis:新发类风湿关节炎的急性冠脉综合征

2017-09-08 xiangting MedSci原创

尽管新发RA的疾病控制得到改善,但RA的ACS风险升高仍是一个问题。

急性冠脉综合征(ACS)和其他心血管疾病是类风湿性关节炎(RA)发病率和过早死亡率升高的主要原因。RA中的ACS与炎症和RA的严重程度相关。近年来,随着新的治疗方案和治疗对策的发展,为RA诊断后尽快达到缓解做出了越来越多的努力,RA疾病活动的平均水平有所下降。这是否会导致RA合并症的过度风险下降尚不清楚。

研究人员对1997年到2014年间的新发RA患者进行了一项全国性的基于人群的队列研究,并与一般人群进行匹配比较。从瑞典风湿病质量登记中确定了15 744例新发RA患者,选出70 899例普通人作为匹配比较对象。

772例RA患者在103 835人年的随访期间(粗发病率,7.4/1000)发生ACS,与普通人群相比的总HR为1.41(95%CI 1.29-1.54)。尽管在RA和普通人群中ACS的发病率均随时间而降低,ACS的过剩和相对风险保持不变。

尽管新发RA的疾病控制得到改善,但RA的ACS风险升高仍是一个问题。

原始出处:

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    2017-09-10 lmm397
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    2017-09-08 131****1460

    学习了受益匪浅

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