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J Viral Hepat：Toll样受体4多态性与印度患者感染戊型肝炎病毒的关系

2018-08-21 MedSci MedSci原创

Toll-likereceptor4多态性hepatitisEvirus
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研究首次报道了TLR4多态性与戊型肝炎的关系，并提示HEV感染时TLR4低反应性可能与其多态性有关。

戊型肝炎病毒(HEV)引起的戊型肝炎感染是发展中国家的一项重大公共卫生问题，是成人散发性和流行性急性病毒性肝炎的病因。人们对戊型肝炎感染的发病机理知之甚少。Toll样受体(TLRs)是固有免疫识别病原体相关分子模式(PAMPs)中的关键角色。

在此之前，研究组发现在HEV感染患者中，TLR 4高表达(在蛋白和基因水平上)与LPS刺激单个核细胞后细胞因子反应受损有关。针对TLR4基因(A299G， C399T)多态性与肝病相关性的早期观察，本研究对HEV感染患者的TLR4多态性进行了探究。

研究观察到TLR4-399CC和CT等位基因与戊型肝炎(亚临床和急性患者)显著相关。与对照组相比，TLR4-399 CT在患者类别中的载波频率较低。TLR4-399C等位基因频率较高与疾病进展显著相关。急性肝病患者CG和TA单倍型的频率更高，而罕见的单倍型(TG)在对照组中更高。TLR4-299 (A>G)上的单核苷酸多态性(SNP)没有显示任何差异。

研究首次报道了TLR4多态性与戊型肝炎的关系，并提示HEV感染时TLR4低反应性可能与其多态性有关。

原始出处

Arya RP， Mishra N， Biswas K， et al. Association of Toll-like receptor 4 polymorphism with Hepatitis E virus infected Indian patients.J Viral Hepat， 2018， Aug 16. doi： 10.1111/jvh.12980.

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    2018-08-23 gwc384

    #EPA#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1427199, encodeId=1b5f142e199c1, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Aug 23 09:20:00 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443105, encodeId=af55144310592, content=<a href='/topic/show?id=34b3538088b' target=_blank style='color:#2F92EE;'>#戊型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53808, encryptionId=34b3538088b, topicName=戊型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=828f5025371, createdName=ms1779634646866130, createdTime=Thu Aug 23 09:20:00 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629267, encodeId=ab57162926e65, content=<a href='/topic/show?id=0c1c4325170' target=_blank style='color:#2F92EE;'>#多态性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43251, encryptionId=0c1c4325170, topicName=多态性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d83c21331263, createdName=xzw120, createdTime=Thu Aug 23 09:20:00 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339974, encodeId=65e53399e406, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Aug 21 18:59:01 CST 2018, time=2018-08-21, status=1, ipAttribution=)]
    2018-08-23 ms1779634646866130

    #戊型肝炎#

    0

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    2018-08-23 xzw120

    #多态性#

    0

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    2018-08-21 清风拂面

    谢谢分享学习

    0

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