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Theranostics:纳米粒子和交变磁场杀死小鼠体内癌细胞

2012-04-10 Beyond 生物谷

佐治亚大学科学家们发现利用纳米粒子和交变磁场可以在半小时内杀死患头颈癌的小鼠体内肿瘤细胞,同时不伤害健康细胞。 相关研究结果发表在Theranostics杂志上,研究人员已经证实可以用磁性氧化铁纳米粒子诱导热疗法来治疗患这种类型癌症的老鼠。 该研究领导者、富兰克林艺术和科学学院物理学助理教授Qun Zhao说:“我们表明低浓度的纳米粒子就可以杀死癌细胞”。 世界各地的研究人员正在探索炽热的纳

佐治亚大学科学家们发现利用纳米粒子和交变磁场可以在半小时内杀死患头颈癌的小鼠体内肿瘤细胞,同时不伤害健康细胞。

相关研究结果发表在Theranostics杂志上,研究人员已经证实可以用磁性氧化铁纳米粒子诱导热疗法来治疗患这种类型癌症的老鼠。

该研究领导者、富兰克林艺术和科学学院物理学助理教授Qun Zhao说:“我们表明低浓度的纳米粒子就可以杀死癌细胞”。

世界各地的研究人员正在探索炽热的纳米粒子能否作为一个潜在的癌症治疗方法。以往的研究还表明铁磁性氧化铁纳米颗粒与较强的交变磁场电流相结合产生的高温足以杀死肿瘤细胞。Zhao说,他本人对研究结果持乐观态度,但要想进入临床试验仍需要开展更多包动物研究。

实验中,研究人员在肿瘤部位注入纳米溶液。鼠麻醉后,老鼠放入有线圈包裹的塑料管内,线圈产生交变磁场。加热线圈产生的磁场只集中在瘤组织内的纳米粒子上,并不影响周围的健康组织。

Zhao说:这项研究为探讨如何利用一种类似磁性氧化铁的可生物降解的纳米材料来治疗癌症(如携带和传递抗癌药物对肿瘤部位)铺平了道路。

Zhao说:当癌细胞遇到这种炽热环境时,会变得对药物很敏感。

他表示磁性氧化铁纳米粒子在改善肿瘤部位磁共振成像检测结果上会有所提高。换句话说就是纳米粒子可以帮助医生检测癌症,即使是那种用核磁共振成像扫描后肉眼也是看不见的癌症类型。

这项研究是由美国国家癌症研究所、埃默里大学头颈癌研究计划资助。(生物谷:Bioon)

doi:10.7150/thno.3854
PMC:
PMID:

Magnetic Nanoparticle-Based Hyperthermia for Head & Neck Cancer in Mouse Models

Qun Zhao, Luning Wang, Rui Cheng, Leidong Mao, Robert D. Arnold, Elizabeth W. Howerth, Zhuo G. Chen, Simon Platt.

In this study, magnetic iron oxide nanoparticle induced hyperthermia is applied for treatment of head and neck cancer using a mouse xenograft model of human head and neck cancer (Tu212 cell line). A hyperthermia system for heating iron oxide nanoparticles was developed by using alternating magnetic fields. Both theoretical simulation and experimental studies were performed to verify the thermotherapy effect. Experimental results showed that the temperature of the tumor center has dramatically elevated from around the room temperature to about 40oC within the first 5-10 minutes. Pathological studies demonstrate epithelial tumor cell destruction associated with the hyperthermia treatment.

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    2012-05-30 海豹
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    2012-04-12 yxch36
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