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Lancet Diabetes Endo:变性为男性的睾酮治疗——风险与获益

2017-05-04 闫盈盈 环球医学

睾酮治疗是变性为男性的药物治疗基础。2017年4月,发表在《Lancet Diabetes Endocrinol》的一篇综述详细阐述了睾酮预期中的作用以及预期外的和不知道的作用,以及目前研究的局限性。睾酮治疗是变性为男性的药物治疗基础。睾酮治疗的目的通常是血清睾酮浓度达到男性参考范围。睾酮具有许多预期中的作用以及预期外的和不知道的作用。预期作用包括增加面部毛发和体毛、增加瘦体重和强度、降低脂肪质量

睾酮治疗是变性为男性的药物治疗基础。2017年4月,发表在《Lancet Diabetes Endocrinol》的一篇综述详细阐述了睾酮预期中的作用以及预期外的和不知道的作用,以及目前研究的局限性。

睾酮治疗是变性为男性的药物治疗基础。睾酮治疗的目的通常是血清睾酮浓度达到男性参考范围。睾酮具有许多预期中的作用以及预期外的和不知道的作用。预期作用包括增加面部毛发和体毛、增加瘦体重和强度、降低脂肪质量、使声音降低,增加性欲、停经、阴蒂扩大和减少性别焦虑、知觉压力、焦虑和抑郁。与此同时,也会同时出现潜在的非预期作用和风险,包括痤疮、脱发、HDL胆固醇的减少、甘油三酯的增加和收缩压的潜在增加。睾酮治疗的额外获益(联合或不联合乳房切除术)是乳腺癌风险的减少。尽管面部毛发和脱发在1年后会出现,但是睾酮治疗的大多数作用是从治疗开始的几个月内出现的。变性男性使用睾酮治疗研究的主要局限性是缺乏高质量证据,这是由于缺少随机对照试验(部分是因为伦理问题)、前瞻性和长期研究较少、使用次优对照组、失访和很难招募到变性为男性人群的代表性样本。

原始出处:

Irwig MS. Testosterone therapy for transgender men.Lancet Diabetes Endocrinol. 2017 Apr;5(4):301-311. doi: 10.1016/S2213-8587(16)00036-X. 

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    2017-07-17 howi
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  5. 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objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Sat May 06 05:20:48 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1384618, encodeId=821b1384618dd, content=<a href='/topic/show?id=3beae3105da' target=_blank style='color:#2F92EE;'>#睾酮治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73105, encryptionId=3beae3105da, topicName=睾酮治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e875489, createdName=wenjie, createdTime=Fri May 05 15:29:00 CST 2017, time=2017-05-05, status=1, ipAttribution=), 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    2017-05-08 ameile

    不错的知识

    0

  6. 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    2017-05-07 惠映实验室

    每次学习,均有收获

    0

  7. 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    2017-05-07 狼毒花1982

    学习了感谢分享

    0

  8. 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    2017-05-06 狼毒花1982

    学习了感谢分享

    0

  9. 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  10. 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GetPortalCommentsPageByObjectIdResponse(id=1463527, encodeId=3d31146352e79, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Fri May 05 15:29:00 CST 2017, time=2017-05-05, status=1, ipAttribution=)]
    2017-05-05 huangdf

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J Clin Endocrinol Metab:孕激素和睾酮联合注射可有效用于男性避孕

目前,仍未有一种安全有效的可逆性男性避孕方法。本研究旨在评估联用孕激素和睾酮注射抑制精子发生和避孕保护的效果。 采用前瞻性多中心研究设计,在十个研究中心,纳入18-45岁的健康男性,以及其18-38岁的女性伴侣,均无生育问题。 对男性参与者进行肌内注射庚酸炔诺酮200毫克和1000毫克睾酮,每8周给药一次。然后通过精液分析精子发生的抑制作用,通过妊娠率来评估避孕保护效果。 结果,

Hypertension:睾酮通过上调miR-22抑制雌激素信号

该研究的结果揭示了在人胎盘中miR-22调节雄激素和雌激素平衡生产的潜在机制,并从调节内分泌的角度为子痫前期的发病机制提供了新的见解。

JAMA:睾酮水平较低的老年男性,睾酮治疗竟增大冠状动脉斑块体积!

2017年2月,发表在《JAMA》的一项由美国科学家进行的研究考察了,在睾酮水平较低的老年男性中,睾酮治疗能否延缓冠状动脉斑块体积进展。 重要性:近期的研究对睾酮治疗是否会增加心血管风险得出了不同的结论。 目的:考察“睾酮水平较低的老年男性使用睾酮治疗可延缓非钙化冠状动脉斑块体积进展”的假设。 设计、地点和受试者:在美国9个学术医疗中心开展的双盲、安慰剂对照试验。受试者为睾酮试验中,2010

ATVB:睾酮转化成雌激素和雄激素衍生物预防男性皮肤缺血坏死

慢性不愈合伤是一个重大医疗问题,与疾病发病率和死亡率相关,因此迫切需要新的治疗策略。考虑性别差异是这一领域迈向个体/精准医学的第一步。缺血削弱受伤的伤口愈合,之前研究证明17β-雌二醇显着防止雌性小鼠缺血诱导的皮瓣坏死。然而,雄性小鼠中睾丸激素的这一领域作用尚未报道。本研究我们使用皮瓣缺血模型研究了雄性小鼠中类固醇激素的作用。去势的雄性小鼠缺血后发生皮肤坏死,而给予睾酮治疗同等保护完整或去势雄性小

JAMA:睾酮能否改善老年男性认知功能?

大部分人的认知功能随着年龄的增长而降低。此前的研究显示,睾酮治疗可以改善这些功能。2017年2月,发表在《JAMA.》的一项研究调查了睾酮水平较低伴年龄相关记忆损伤老年男性中,睾酮治疗能否改善认知功能。

BMJ:睾酮治疗与静脉血栓栓塞风险增加有关

由此可见,开始睾酮治疗与静脉血栓栓塞的风险增加有关,并在六个月内达到高峰,此后下降。

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