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Phytother Res：四羟基二苯乙烯苷对链脲佐菌素诱导的高血糖小鼠糖尿病引起的骨质疏松症有保护作用

2018-11-22 MedSci MedSci原创

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四羟基二苯乙烯苷（TSG）是一种药用植物何首乌（Polygonum multiflorum Thunb）的活性成分，可以阻断组织肾素-血管紧张素系统（RAS）的活性，该系统在糖尿病性骨质疏松症的发展中起着关键作用。本研究旨在确定TSG治疗是否可以缓解由链脲佐菌素诱导的糖尿病小鼠模型中的骨质恶化。 结果显示，与非糖尿病小鼠相比，糖尿病小鼠股骨远端干骺端骨小梁骨量减少，骨小梁微结构参数变化，抗酒

四羟基二苯乙烯苷（TSG）是一种药用植物何首乌（Polygonum multiflorum Thunb）的活性成分，可以阻断组织肾素-血管紧张素系统（RAS）的活性，该系统在糖尿病性骨质疏松症的发展中起着关键作用。本研究旨在确定TSG治疗是否可以缓解由链脲佐菌素诱导的糖尿病小鼠模型中的骨质恶化。

结果显示，与非糖尿病小鼠相比，糖尿病小鼠股骨远端干骺端骨小梁骨量减少，骨小梁微结构参数变化，抗酒石酸酸性磷酸酶（TRAP）阳性破骨细胞数量增加。TSG治疗明显提高血清和骨骼中的钙含量，改善骨小梁的生物学参数，同时增加RUNX-2，COL-1和OCN的信使RNA（mRNA）表达和β-连环蛋白的蛋白表达以及降低调节RAS组分的蛋白质表达，包括肾素和AT1R。此外，TSG抑制糖尿病诱导的OPG/RANKL表达比率降低和骨中硬化蛋白表达增加。在MC3T3-E1细胞中发现了TSG对成骨细胞特异性基因的类似作用。

总之，本研究证实了TSG在糖尿病小鼠中的骨保护作用，其潜在机制可能归因于其对成骨和破骨细胞生成的调节。

原始出处：

Zhang J, Chen X, et al., Tetrahydroxy stilbene glucoside protected against diabetes-induced osteoporosis in mice with streptozotocin-induced hyperglycemia. Phytother Res. 2018 Nov 19. doi: 10.1002/ptr.6240.

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    2018-11-24 orangesking

    好

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=353568, encodeId=8db6353568b8, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Sat Nov 24 21:31:43 CST 2018, time=2018-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261169, encodeId=0621126116956, content=<a href='/topic/show?id=30c6102e2607' target=_blank style='color:#2F92EE;'>#高血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102726, encryptionId=30c6102e2607, topicName=高血糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Nov 24 14:33:00 CST 2018, time=2018-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592517, encodeId=b72d159251e4a, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sat Nov 24 14:33:00 CST 2018, time=2018-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599104, encodeId=c1a1159910460, content=<a href='/topic/show?id=f14d2e187ac' target=_blank style='color:#2F92EE;'>#保护作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27187, encryptionId=f14d2e187ac, topicName=保护作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Sat Nov 24 14:33:00 CST 2018, time=2018-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042054, encodeId=c6ff1042054b0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Nov 23 02:33:00 CST 2018, time=2018-11-23, status=1, ipAttribution=)]
    2018-11-24 hbwxf

    #高血糖#

    0

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    2018-11-24 Eleven17

    #骨质#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=353568, encodeId=8db6353568b8, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Sat Nov 24 21:31:43 CST 2018, time=2018-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261169, encodeId=0621126116956, content=<a href='/topic/show?id=30c6102e2607' target=_blank style='color:#2F92EE;'>#高血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102726, encryptionId=30c6102e2607, topicName=高血糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Nov 24 14:33:00 CST 2018, time=2018-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592517, encodeId=b72d159251e4a, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sat Nov 24 14:33:00 CST 2018, time=2018-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599104, encodeId=c1a1159910460, content=<a href='/topic/show?id=f14d2e187ac' target=_blank style='color:#2F92EE;'>#保护作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27187, encryptionId=f14d2e187ac, topicName=保护作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Sat Nov 24 14:33:00 CST 2018, time=2018-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042054, encodeId=c6ff1042054b0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Nov 23 02:33:00 CST 2018, time=2018-11-23, status=1, ipAttribution=)]
    2018-11-24 智慧医人

    #保护作用#

    0

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    2018-11-23 misszhang

    谢谢MedSci提供最新的资讯

    0

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