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Stroke:急性缺血性卒中患者肌钙蛋白和超声心动图的阳性率及其与患者死亡率的关系如何?

2017-04-06 xing.T MedSci原创

在没有并发心肌梗死的AIS患者中高肌钙蛋白血症与结构性心脏病和长期死亡率相关。但仍需要进行前瞻性研究以确定进一步的心脏评估是否会改善这类患者的长期死亡率。

急性缺血性卒中(AIS)患者入院时血清心肌肌钙蛋白水平可能升高,然而这对预后的影响以及其升高的水平是否与卒中的心脏原因或经超声心动图发现的结构性心脏疾病有关尚不清楚。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员在一个大型混血AIS人群中调查了心肌肌钙蛋白和超声心动图检测的阳性率以及与卒中后死亡之间的任何关联。

在医院服务的130万民众中,研究人员通过回顾性病历审查筛选了2010年后经急诊科入院的根据国际疾病分类第九版出院代码为430至436的并经医生确认的所有AIS病例。高肌钙蛋白血症被定义为肌钙蛋白升高并高于标准的第九十九百分数。控制卒中的严重程度、心脏疾病史和所有其他卒中危险因素后,进行多因素Logistic回归分析。

在1999例AIS病例中,1706例(85.3%)患者进行了心肌肌钙蛋白测定,1590例(79.5%)患者进行了超声心动图检查。1706例患者中有353例(20.7%)患者发生高肌钙蛋白血症,1590例患者中有160例(10.1%)患者出现了感兴趣的超声心动图结果。在1377两项检查均进行的患者中,研究人员发现高肌钙蛋白血症与超声心动图结果独立相关(比值比为2.9;95%可信区间为2-4.2)。当并发心肌梗塞(3.5%)被排除后,高肌钙蛋白血症也与1年(35%;比值比为3.45;95%可信区间为2.1-5.6)和3年(60%;比值比为2.91;95%可信区间为2.06-4.11)死亡率增加有关。

在没有并发心肌梗死的AIS患者中高肌钙蛋白血症与结构性心脏病和长期死亡率相关。但仍需要进行前瞻性研究以确定进一步的心脏评估是否会改善这类患者的长期死亡率。

原始出处:

Peter Wrigley,et al. Prevalence of Positive Troponin and Echocardiogram Findings and Association With Mortality in Acute Ischemic Stroke.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.116.014561

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beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79360, encryptionId=9cf7e9360d2, topicName=缺血性卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=/img/user_icon.png, createdBy=1072181, createdName=wjywjy, createdTime=Thu Sep 21 22:41:00 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186271, encodeId=99061862e142, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2emBzjO0FtqTJ05AqrEEdRmp6tmlsLXqpzfxWdtgbbgPGWRHagoK9fLTd3IayRPgkJVIVBWtdlmnkBhOIR4cFM/0, createdBy=e8d51649330, createdName=飘飘爱, createdTime=Sun Apr 09 22:36:24 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185889, encodeId=af09185889cd, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Apr 08 06:16:37 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185794, encodeId=32b4185e94cc, content=数据库可以回答好多问题,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Fri Apr 07 15:05:27 CST 2017, time=2017-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185786, encodeId=ed55185e86a6, content=jjjkko, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/23/866d85f7b1582f7bc2026a70028af6af.jpg, createdBy=19631734342, createdName=1def578fm19(暂无匿称), createdTime=Fri Apr 07 13:50:48 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-09 飘飘爱

    很好

    0

  8. 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2017, time=2017-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185786, encodeId=ed55185e86a6, content=jjjkko, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/23/866d85f7b1582f7bc2026a70028af6af.jpg, createdBy=19631734342, createdName=1def578fm19(暂无匿称), createdTime=Fri Apr 07 13:50:48 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-08 1e10c84am36(暂无匿称)

    文章不错,值得分享

    0

  9. 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encodeId=af09185889cd, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Apr 08 06:16:37 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185794, encodeId=32b4185e94cc, content=数据库可以回答好多问题,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Fri Apr 07 15:05:27 CST 2017, time=2017-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185786, encodeId=ed55185e86a6, content=jjjkko, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/23/866d85f7b1582f7bc2026a70028af6af.jpg, createdBy=19631734342, createdName=1def578fm19(暂无匿称), createdTime=Fri Apr 07 13:50:48 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-07 baihao215

    数据库可以回答好多问题,学习了

    0

  10. 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encodeId=af09185889cd, content=文章不错,值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Apr 08 06:16:37 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185794, encodeId=32b4185e94cc, content=数据库可以回答好多问题,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Fri Apr 07 15:05:27 CST 2017, time=2017-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185786, encodeId=ed55185e86a6, content=jjjkko, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/23/866d85f7b1582f7bc2026a70028af6af.jpg, createdBy=19631734342, createdName=1def578fm19(暂无匿称), createdTime=Fri Apr 07 13:50:48 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-07 1def578fm19(暂无匿称)

    jjjkko

    0

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