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LPS:胰腺癌迎来全新突破,双热消融全面清除癌细胞

2018-02-27 Heather_z727译自 medicalxpress 来宝网

据宾厄姆顿大学的新研究,加热和冷冻的过程称为双热消融可以杀死胰腺癌细胞。

据宾厄姆顿大学的新研究,加热和冷冻的过程称为双热消融可以杀死胰腺癌细胞。

当化疗和放疗根本不起作用时,如何解决胰腺癌的问题?为了弄明白这一问题,来自据宾厄姆顿大学的研究人员们专门在实验室中培养了胰腺癌细胞,基本的问题是,冻结和热结合比冻结或加热单独使用更加有效。

研究人员加热加冻结癌细胞并观察其效果,使用各种技术来测定细胞死亡水平、再生以及细胞应激通路的激活。使用各种分析方法,我们能够确定细胞死亡的初始水平,我们还能够确定由于双重热暴露而激活的细胞死亡的具体路径。

研究人员表示:“当细胞受到干扰时,他们被冻结或他们看到热,各种细胞应激通路被激活,关于细胞,特别是癌细胞,它们会激活保护自身的途径。这一系列基于分子的研究的目的是找出胰腺癌细胞中哪些应激途径会被激活,以便我们更好地理解为什么双热消融更加有效。目前的研究主要集中在阐明哪些应激途径特别导致这些细胞死亡或什么使它们存活。这样,我们可以优化处理是尽可能有效对抗胰腺癌。”

调节这些应力途径是使加热和冷冻消融过程更加有效的关键,这将带来一种新的方法来应对胰腺癌。除了细胞分子研究之外,研究小组的几名成员正在开发新的导管技术,将这种消融疗法提供给患者。“如果可以研制出一种非常薄的导管来针对肿瘤,我们能够从分子水平了解胰腺癌对消融的反应,那么我们就可能开发出一种新的治疗方法,来处理一些完全无法接近的细胞。”

原始出处:Kenneth W. Baumann, John M. Baust, Kristi K. Snyder, et al. Dual thermal ablation of pancreatic cancer cells as an improved combinatorial treatment strategy. Liver and Pancreatic Sciences (2018)

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    2018-11-06 zxxiang
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    2018-09-20 爱吃鱼的菜

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    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1724972, encodeId=2ef71e2497213, content=<a href='/topic/show?id=9ee758586bb' target=_blank style='color:#2F92EE;'>#新突破#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58586, encryptionId=9ee758586bb, topicName=新突破)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=792a33728807, createdName=zxxiang, createdTime=Tue Nov 06 22:33:00 CST 2018, time=2018-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634238, encodeId=7f4b163423851, content=<a href='/topic/show?id=5abf6e2114f' target=_blank style='color:#2F92EE;'>#热消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67211, encryptionId=5abf6e2114f, topicName=热消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=04a722134767, createdName=花花1373, createdTime=Mon Oct 15 05:33:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345897, encodeId=8f3934589ee6, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Thu Sep 20 22:35:46 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345254, encodeId=63f834525494, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Sun Sep 16 18:30:05 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345023, encodeId=3a27345023e2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Fri Sep 14 23:07:18 CST 2018, time=2018-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344884, encodeId=7e843448848e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Thu Sep 13 22:48:50 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344745, encodeId=7e76344e4503, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Wed Sep 12 23:08:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344522, encodeId=b05034452270, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Tue Sep 11 13:41:25 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344421, encodeId=222634442190, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Mon Sep 10 22:16:36 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344154, encodeId=a519344154f0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Sun Sep 09 12:16:09 CST 2018, time=2018-09-09, status=1, ipAttribution=)]
    2018-09-16 爱吃鱼的菜

    学习

    0

  5. 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createdBy=04a722134767, createdName=花花1373, createdTime=Mon Oct 15 05:33:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345897, encodeId=8f3934589ee6, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Thu Sep 20 22:35:46 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345254, encodeId=63f834525494, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Thu Sep 13 22:48:50 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344745, encodeId=7e76344e4503, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Wed Sep 12 23:08:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344522, encodeId=b05034452270, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Tue Sep 11 13:41:25 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344421, encodeId=222634442190, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Mon Sep 10 22:16:36 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344154, encodeId=a519344154f0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Sun Sep 09 12:16:09 CST 2018, time=2018-09-09, status=1, ipAttribution=)]
    2018-09-14 爱吃鱼的菜

    学习

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Thu Sep 13 22:48:50 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344745, encodeId=7e76344e4503, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Wed Sep 12 23:08:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344522, encodeId=b05034452270, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Tue Sep 11 13:41:25 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344421, encodeId=222634442190, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Mon Sep 10 22:16:36 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344154, encodeId=a519344154f0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Sun Sep 09 12:16:09 CST 2018, time=2018-09-09, status=1, ipAttribution=)]
    2018-09-13 爱吃鱼的菜

    学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1724972, encodeId=2ef71e2497213, content=<a href='/topic/show?id=9ee758586bb' target=_blank style='color:#2F92EE;'>#新突破#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58586, encryptionId=9ee758586bb, topicName=新突破)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=792a33728807, createdName=zxxiang, createdTime=Tue Nov 06 22:33:00 CST 2018, time=2018-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634238, encodeId=7f4b163423851, content=<a href='/topic/show?id=5abf6e2114f' target=_blank style='color:#2F92EE;'>#热消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67211, encryptionId=5abf6e2114f, topicName=热消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=04a722134767, createdName=花花1373, createdTime=Mon Oct 15 05:33:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345897, encodeId=8f3934589ee6, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Thu Sep 20 22:35:46 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345254, encodeId=63f834525494, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Sun Sep 16 18:30:05 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345023, encodeId=3a27345023e2, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Fri Sep 14 23:07:18 CST 2018, time=2018-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344884, encodeId=7e843448848e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Thu Sep 13 22:48:50 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344745, encodeId=7e76344e4503, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Wed Sep 12 23:08:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344522, encodeId=b05034452270, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Tue Sep 11 13:41:25 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344421, encodeId=222634442190, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Mon Sep 10 22:16:36 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344154, encodeId=a519344154f0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Sun Sep 09 12:16:09 CST 2018, time=2018-09-09, status=1, ipAttribution=)]
    2018-09-12 爱吃鱼的菜

    学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1724972, encodeId=2ef71e2497213, content=<a href='/topic/show?id=9ee758586bb' target=_blank style='color:#2F92EE;'>#新突破#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58586, encryptionId=9ee758586bb, topicName=新突破)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=792a33728807, createdName=zxxiang, createdTime=Tue Nov 06 22:33:00 CST 2018, time=2018-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634238, encodeId=7f4b163423851, content=<a href='/topic/show?id=5abf6e2114f' target=_blank style='color:#2F92EE;'>#热消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67211, encryptionId=5abf6e2114f, topicName=热消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=04a722134767, createdName=花花1373, createdTime=Mon Oct 15 05:33:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345897, encodeId=8f3934589ee6, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Thu Sep 20 22:35:46 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345254, encodeId=63f834525494, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Thu Sep 13 22:48:50 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344745, encodeId=7e76344e4503, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Wed Sep 12 23:08:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344522, encodeId=b05034452270, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Tue Sep 11 13:41:25 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344421, encodeId=222634442190, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Mon Sep 10 22:16:36 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344154, encodeId=a519344154f0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Sun Sep 09 12:16:09 CST 2018, time=2018-09-09, status=1, ipAttribution=)]
    2018-09-11 爱吃鱼的菜

    学习

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Thu Sep 13 22:48:50 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344745, encodeId=7e76344e4503, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Wed Sep 12 23:08:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344522, encodeId=b05034452270, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Tue Sep 11 13:41:25 CST 2018, time=2018-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344421, encodeId=222634442190, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Mon Sep 10 22:16:36 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344154, encodeId=a519344154f0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/NTic9Miaqzd45vaDM0ekLB3vNS5HOYHY9qazsphRvB9G0fykOZXgCUCLcoia97nvrAvJNk3KDbDGpGQWecDYMvEMQ/132, createdBy=6a7b2264890, createdName=爱吃鱼的菜, createdTime=Sun Sep 09 12:16:09 CST 2018, time=2018-09-09, status=1, ipAttribution=)]
    2018-09-10 爱吃鱼的菜

    学习

    0

  10. 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    2018-09-09 爱吃鱼的菜

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