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Gastroenterology:膳食纤维摄入与胃癌发生风险呈负相关

2013-08-06 吴军 编译 cmt

许多研究探讨了膳食纤维摄入与胃癌风险的关系,但是结论不一致。近日,来自江苏南京大学医学院的Zhizhong Zhang等进行了以病例对照研究和队列研究为主的一项荟萃分析,评价两者之间的关系。研究显示膳食纤维摄入与胃癌发生风险呈负相关,在所有研究中,膳食纤维的作用均一致,但由于各研究之间存在异质性,结论的绝对可靠度不明确,需要进一步的研究来明确两者之间的关系。该文近期发表于2013年第14

许多研究探讨了膳食纤维摄入与胃癌风险的关系,但是结论不一致。近日,来自江苏南京大学医学院的Zhizhong Zhang等进行了以病例对照研究和队列研究为主的一项荟萃分析,评价两者之间的关系。研究显示膳食纤维摄入与胃癌发生风险呈负相关,在所有研究中,膳食纤维的作用均一致,但由于各研究之间存在异质性,结论的绝对可靠度不明确,需要进一步的研究来明确两者之间的关系。该文近期发表于2013年第145卷第1期《胃肠病学》(Gastroenterology)杂志。

研究者在Pubmed及Embase 数据库搜索了截止2012年12月的所有相关研究,共纳入21篇文章,58064例患者。采用随机效应模型评估相对风险。并进行剂量反应,亚组分析,敏感性分析,Meta回归和出版偏移等分析。

胃癌发生的最高风险与最低风险相比,膳食纤维摄入的总OR值为0.58(95%可信区间, 0.49−0.67),各项研究之间异质性明显 (P < 0.001,I2 = 62.2%)。根据研究类型,地域差别,膳食纤维的来源及类型,Lauren分型,出版日期,样本量及文章质量进行的分层分析,显示出一致的结果。10克/天膳食纤维摄入增加量的相关分析显示胃癌风险减少44%。敏感性分析显示类似的结果,去除任意一项研究对于合并的风险评估结果影响较小。

Zhizhong Zhang, Gelin Xu, Minmin Ma, Jie Yang, Xinfeng Liu.Dietary Fiber Intake Reduces Risk for Gastric Cancer: A Meta-analysis.Received 20 November 2012; accepted 1 April 2013. published online 08 April 2013.

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    2013-09-25 许安
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    2013-08-08 zhaojie88
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1710652, encodeId=30de1e10652ac, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Jun 25 03:44:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071489, encodeId=82e220e148930, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Sep 25 05:44:00 CST 2013, time=2013-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350270, encodeId=380e13502e0b2, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 08 05:44:00 CST 2013, time=2013-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466268, encodeId=f63914662683f, content=<a href='/topic/show?id=afda85920c3' target=_blank style='color:#2F92EE;'>#膳食纤维摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85920, encryptionId=afda85920c3, topicName=膳食纤维摄入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dea96793953, createdName=linne322, createdTime=Thu Aug 08 05:44:00 CST 2013, time=2013-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504153, encodeId=10f11504153a9, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Aug 08 05:44:00 CST 2013, time=2013-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573206, encodeId=398615e3206a3, content=<a href='/topic/show?id=34009226531' target=_blank style='color:#2F92EE;'>#负相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92265, encryptionId=34009226531, topicName=负相关)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c2115837741, createdName=hmwwww, createdTime=Thu Aug 08 05:44:00 CST 2013, time=2013-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063845, encodeId=787a20638458b, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Nov 03 06:44:00 CST 2013, time=2013-11-03, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1710652, encodeId=30de1e10652ac, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Jun 25 03:44:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071489, encodeId=82e220e148930, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Sep 25 05:44:00 CST 2013, time=2013-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350270, encodeId=380e13502e0b2, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 08 05:44:00 CST 2013, time=2013-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466268, encodeId=f63914662683f, content=<a href='/topic/show?id=afda85920c3' target=_blank style='color:#2F92EE;'>#膳食纤维摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85920, encryptionId=afda85920c3, topicName=膳食纤维摄入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dea96793953, createdName=linne322, createdTime=Thu Aug 08 05:44:00 CST 2013, time=2013-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504153, encodeId=10f11504153a9, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Aug 08 05:44:00 CST 2013, time=2013-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573206, encodeId=398615e3206a3, content=<a href='/topic/show?id=34009226531' target=_blank style='color:#2F92EE;'>#负相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92265, encryptionId=34009226531, topicName=负相关)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c2115837741, createdName=hmwwww, createdTime=Thu Aug 08 05:44:00 CST 2013, time=2013-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063845, encodeId=787a20638458b, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Nov 03 06:44:00 CST 2013, time=2013-11-03, status=1, ipAttribution=)]
    2013-08-08 hmwwww
  7. [GetPortalCommentsPageByObjectIdResponse(id=1710652, encodeId=30de1e10652ac, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Jun 25 03:44:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071489, encodeId=82e220e148930, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Sep 25 05:44:00 CST 2013, time=2013-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350270, encodeId=380e13502e0b2, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Aug 08 05:44:00 CST 2013, time=2013-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466268, encodeId=f63914662683f, content=<a href='/topic/show?id=afda85920c3' target=_blank style='color:#2F92EE;'>#膳食纤维摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85920, encryptionId=afda85920c3, topicName=膳食纤维摄入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dea96793953, createdName=linne322, createdTime=Thu Aug 08 05:44:00 CST 2013, time=2013-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504153, encodeId=10f11504153a9, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Aug 08 05:44:00 CST 2013, time=2013-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573206, encodeId=398615e3206a3, content=<a href='/topic/show?id=34009226531' target=_blank style='color:#2F92EE;'>#负相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92265, encryptionId=34009226531, topicName=负相关)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c2115837741, createdName=hmwwww, createdTime=Thu Aug 08 05:44:00 CST 2013, time=2013-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063845, encodeId=787a20638458b, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Nov 03 06:44:00 CST 2013, time=2013-11-03, status=1, ipAttribution=)]
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