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Int J COPD:电子烟和烟草烟雾暴露对COPD支气管上皮细胞炎症反应的影响

2018-04-01 刘毅 呼吸界

电子香烟一直以来是医学上及大众中常见的卷烟代替物用来戒烟过渡物,但一直以来其对人体呼吸道的具体影响并不清楚,本研究通过对电子烟烟雾提取物刺激人类支气管上皮细胞,并发现该提取物的毒性反应机制,引起了同仁的高度重视。

推荐理由:

电子香烟一直以来是医学上及大众中常见的卷烟代替物用来戒烟过渡物,但一直以来其对人体呼吸道的具体影响并不清楚,本研究通过对电子烟烟雾提取物刺激人类支气管上皮细胞,并发现该提取物的毒性反应机制,引起了同仁的高度重视。

背景:

电子香烟(电子烟)用于帮助戒烟。但是,这些设备含有有害化学物质,存在安全隐患。我们研究了电子烟对COPD支气管上皮细胞(BECs)的炎症反应和活力的影响。

方法:

将COPD患者和对照的BECs暴露于电子烟烟雾提取物(ECVE),测定白细胞介素(IL)-6,CXCL8的水平和乳酸脱氢酶释放水平。我们还检测了用polyinosinic:polycytidylic acid(polyI:C)刺激ECVE预处理BECs释放的细胞因子水平。使用Calu-3细胞进行平行实验。用香烟烟雾提取物(CSE)做对照。

结果:

ECVE和CSE引起Calu-3细胞释放IL-6和CXCL8的增加。 ECVE仅在BECs和Calu-3细胞中引起毒性。此外,ECVE和CSE可抑制这两种细胞培养模型中poly I:C-刺激的C-X-C基序配体10释放,在0.3的光密度下达到CSE的作用具有统计学意义。

结论:

ECVE引起毒性并降低对poly I:C的抗毒反应。这引起了对电子烟使用安全的担忧。

原始出处:
 Higham A, Bostock D, Booth G, et al. The effect of electronic cigarette and tobacco smoke exposure on COPD bronchial epithelial cell inflammatory responses.  International Journal of Chronic Obstructive Pulmonary Disease. 23 March 2018 Volume 2018:13 Pages 989—1000.

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    2018-04-08 871538379

    看来还是建议病人要彻底戒烟

    0

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topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Tue Apr 03 01:48:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533856, encodeId=b634153385676, content=<a href='/topic/show?id=4be9200308c' target=_blank style='color:#2F92EE;'>#上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20030, encryptionId=4be9200308c, topicName=上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a5d12492718, createdName=lizhou0208, createdTime=Tue Apr 03 01:48:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301965, encodeId=64d03019650c, content=学习了很多先进的医学知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Mon Apr 02 07:12:41 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301750, encodeId=2759301e50bf, content=v高哈哈哈还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Apr 01 11:21:31 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301739, encodeId=bd0f301e396d, content=学习了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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  5. 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topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Tue Apr 03 01:48:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533856, encodeId=b634153385676, content=<a href='/topic/show?id=4be9200308c' target=_blank style='color:#2F92EE;'>#上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20030, encryptionId=4be9200308c, topicName=上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a5d12492718, createdName=lizhou0208, createdTime=Tue Apr 03 01:48:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301965, encodeId=64d03019650c, content=学习了很多先进的医学知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Mon Apr 02 07:12:41 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301750, encodeId=2759301e50bf, content=v高哈哈哈还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Apr 01 11:21:31 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301739, encodeId=bd0f301e396d, content=学习了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/07/d51783575d8d90eaa8b668d568aa6e50.jpg, createdBy=909f109204, createdName=liuweigang, createdTime=Sun Apr 01 10:56:04 CST 2018, time=2018-04-01, status=1, ipAttribution=)]
    2018-04-03 mnda
  6. 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attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Mon Apr 02 07:12:41 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301750, encodeId=2759301e50bf, content=v高哈哈哈还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Apr 01 11:21:31 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301739, encodeId=bd0f301e396d, content=学习了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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  7. 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  8. 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topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Tue Apr 03 01:48:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533856, encodeId=b634153385676, content=<a href='/topic/show?id=4be9200308c' target=_blank style='color:#2F92EE;'>#上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20030, encryptionId=4be9200308c, topicName=上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a5d12492718, createdName=lizhou0208, createdTime=Tue Apr 03 01:48:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301965, encodeId=64d03019650c, content=学习了很多先进的医学知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Mon Apr 02 07:12:41 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301750, encodeId=2759301e50bf, content=v高哈哈哈还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Apr 01 11:21:31 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301739, encodeId=bd0f301e396d, content=学习了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/07/d51783575d8d90eaa8b668d568aa6e50.jpg, createdBy=909f109204, createdName=liuweigang, createdTime=Sun Apr 01 10:56:04 CST 2018, time=2018-04-01, status=1, ipAttribution=)]
    2018-04-02 雅文博武

    学习了很多先进的医学知识

    0

  9. 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topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Tue Apr 03 01:48:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533856, encodeId=b634153385676, content=<a href='/topic/show?id=4be9200308c' target=_blank style='color:#2F92EE;'>#上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20030, encryptionId=4be9200308c, topicName=上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a5d12492718, createdName=lizhou0208, createdTime=Tue Apr 03 01:48:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301965, encodeId=64d03019650c, content=学习了很多先进的医学知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Mon Apr 02 07:12:41 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301750, encodeId=2759301e50bf, content=v高哈哈哈还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Apr 01 11:21:31 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301739, encodeId=bd0f301e396d, content=学习了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/07/d51783575d8d90eaa8b668d568aa6e50.jpg, createdBy=909f109204, createdName=liuweigang, createdTime=Sun Apr 01 10:56:04 CST 2018, time=2018-04-01, status=1, ipAttribution=)]
    2018-04-01 为你把脉

    v高哈哈哈还好还好哈

    0

  10. 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topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Tue Apr 03 01:48:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533856, encodeId=b634153385676, content=<a href='/topic/show?id=4be9200308c' target=_blank style='color:#2F92EE;'>#上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20030, encryptionId=4be9200308c, topicName=上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a5d12492718, createdName=lizhou0208, createdTime=Tue Apr 03 01:48:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301965, encodeId=64d03019650c, content=学习了很多先进的医学知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Mon Apr 02 07:12:41 CST 2018, time=2018-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301750, encodeId=2759301e50bf, content=v高哈哈哈还好还好哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Sun Apr 01 11:21:31 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301739, encodeId=bd0f301e396d, content=学习了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/07/d51783575d8d90eaa8b668d568aa6e50.jpg, createdBy=909f109204, createdName=liuweigang, createdTime=Sun Apr 01 10:56:04 CST 2018, time=2018-04-01, status=1, ipAttribution=)]
    2018-04-01 liuweigang

    学习了解了解

    0

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