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Am J Psychiat:焦虑增加是老年痴呆症的早期预警!

2018-01-13 佚名 medicalnewstoday

焦虑症在美国很普遍,每年大约有4000万成年人受到影响。然而,如果这些忧虑和恐惧的情绪不足以应付的话,很可能很危险。一项新的研究表明老年人焦虑症状的恶化可能更容易患上老年痴呆症。

焦虑症在美国很普遍,每年大约有4000万成年人受到影响。然而,如果这些忧虑和恐惧的情绪不足以应付的话,很可能很危险。一项新的研究表明老年人焦虑症状的恶化可能更容易患上老年痴呆症。

研究人员将老年人的焦虑症状与老年痴呆症相关的蛋白质水平增高联系起来。研究人员发现,越来越多的焦虑症状与β-淀粉样蛋白的水平有关,β淀粉样蛋白是一种与老年痴呆症有关的蛋白质,在正常认知功能的老年人的大脑中。

来自布莱根妇女医院的研究人员表明,焦虑症状上升可能是老年痴呆的早期症状这些发现最近发表在《美国精神病学杂志》上。

阿尔茨海默病是一种痴呆症,其症状是记忆和思维以及行为的改变。据估计,美国大约有550万人患有老年痴呆症,其中65岁以上的人约占540万。阿尔茨海默病的确切病因还不清楚,但科学家认为β淀粉样蛋白起关键作用。这是一种可以形成“斑块”的蛋白质,它可以阻止阿尔茨海默氏症患者大脑中的神经细胞通讯。这些斑块是该病的一个特征,研究表明,β-淀粉样蛋白水平的增加可能发生在阿尔茨海默氏症发病前10年。

根据这项新的研究,焦虑会使β淀粉样蛋白增加,这项研究包括270名年龄在62岁到90岁之间的成年人,他们的认知功能正常,他们都在研究基线时接受了正电子发射断层扫描,并在5年的随访期间每年进行一次,以确定他们大脑中β淀粉样蛋白的水平。采用30项老年抑郁量表评定成人焦虑、抑郁症状。

研究发现,在5年的随访中,焦虑症状增加的成年人大脑中的β淀粉样蛋白水平也较高。研究人员说,这表明焦虑症的恶化可能是阿尔茨海默病的早期征兆。“如果进一步的研究证实焦虑是一种早期指标,那么这不仅对早期发现患者,而且对治疗焦虑有可能减缓或预防早期疾病的进展都很重要。”
原始出处:
Nancy J. Donovan,Nancy J. Donovan, Gad A. Marshall,et al.Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults. The American Journal of Psychiatry.January 12, 2018.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1836175, encodeId=7cd618361e5b3, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Apr 10 10:00:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278524, encodeId=b56a2e85247a, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jan 14 23:04:21 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278456, encodeId=e2bd2e845674, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jan 14 13:55:45 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050444, encodeId=5bbf10504449f, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Jan 14 01:00:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278260, encodeId=dc062e8260f9, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sat Jan 13 23:49:59 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
    2018-04-10 Boyinsh
  2. [GetPortalCommentsPageByObjectIdResponse(id=1836175, encodeId=7cd618361e5b3, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Apr 10 10:00:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278524, encodeId=b56a2e85247a, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jan 14 23:04:21 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278456, encodeId=e2bd2e845674, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jan 14 13:55:45 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050444, encodeId=5bbf10504449f, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Jan 14 01:00:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278260, encodeId=dc062e8260f9, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sat Jan 13 23:49:59 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
    2018-01-14 131****2916

    不错的文章值得推荐

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1836175, encodeId=7cd618361e5b3, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Apr 10 10:00:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278524, encodeId=b56a2e85247a, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jan 14 23:04:21 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278456, encodeId=e2bd2e845674, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jan 14 13:55:45 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050444, encodeId=5bbf10504449f, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Jan 14 01:00:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278260, encodeId=dc062e8260f9, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sat Jan 13 23:49:59 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
    2018-01-14 虈亣靌

    谢谢分享.学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1836175, encodeId=7cd618361e5b3, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Apr 10 10:00:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278524, encodeId=b56a2e85247a, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jan 14 23:04:21 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278456, encodeId=e2bd2e845674, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jan 14 13:55:45 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050444, encodeId=5bbf10504449f, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Jan 14 01:00:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278260, encodeId=dc062e8260f9, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sat Jan 13 23:49:59 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
    2018-01-14 明天jing

    焦虑是当年年轻人的共同问题,需要认真对待。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1836175, encodeId=7cd618361e5b3, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Tue Apr 10 10:00:00 CST 2018, time=2018-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278524, encodeId=b56a2e85247a, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Jan 14 23:04:21 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278456, encodeId=e2bd2e845674, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jan 14 13:55:45 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050444, encodeId=5bbf10504449f, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sun Jan 14 01:00:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278260, encodeId=dc062e8260f9, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Sat Jan 13 23:49:59 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
    2018-01-13 戒馋,懒,贪

    谢谢分享学习了

    0

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