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CPP：研究发现伊立替康诱导的中性粒细胞减少症相关基因

2014-05-05 秀荣 医学论坛网

伊立替康　中性粒细胞减少症
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中性粒细胞减少症是伊立替康引起的可危及患者生命的一种副反应，尿苷二磷酸葡醛酸转移酶(UGTs)基因多态性被认为是与伊立替康相关毒性的一个预测指标。多项研究已表明，携带UGT1A1*28的患者因伊立替康毒性发生重度中性粒细胞减少症的风险较高。然而，UGT1A1 (TA7/TA7)在亚洲人群中却很罕见。一些研究者报告称UGT1A1*28或/和UGT1A1*6可在亚洲人群中对伊立替康诱导的毒性反应进行预

中性粒细胞减少症是伊立替康引起的可危及患者生命的一种副反应，尿苷二磷酸葡醛酸转移酶(UGTs)基因多态性被认为是与伊立替康相关毒性的一个预测指标。多项研究已表明，携带UGT1A1*28的患者因伊立替康毒性发生重度中性粒细胞减少症的风险较高。然而，UGT1A1 (TA7/TA7)在亚洲人群中却很罕见。一些研究者报告称UGT1A1*28或/和UGT1A1*6可在亚洲人群中对伊立替康诱导的毒性反应进行预测，但这结论至今仍有争议。近期，中国学者研究发现，在亚洲癌症患者中，基因型UGT1A1*6和UGT1A1*6/*28与伊立替康诱导的中性粒细胞减少症的发生风险增加具有关联性。论文2014年4月1日在线发表于《癌症化疗与药理学》（Cancer Chemotherapy and Pharmacology）杂志。

该研究采用荟萃分析对UGT1A1*6或UGT1A1*6/*28与伊立替康诱导的中性粒细胞减少症之间的关系进行评估。

结果为，与携带UGT1A1*1等位基因的患者相比，携带基因型UGT1A1*6的患者发生中性粒细胞减少症的风险显著较高【优势比(OR) 3.276；95 %置信区间(CI) 1.887～5.688；P = 0.000 (*6/*6 vs. *1/*6 or *1/*1)】；【OR 1.542; 95 % CI 1.180～2.041; P = 0.001 (*6/*6 or *1/*6 vs. *1/*1)】。同时，携带UGT1A1*6/*28的患者比携带UGT1A1*1等位基因的患者发生中性粒细胞减少症的风险也明显较高【OR 3.275; 95 % CI 2.152～4.983; P = 0.000 (*6/*6 or *28/*28 or *6/*28 vs. *1/*6 or *1/*28 or *1/*1)】。

原始出处：

Han FF1, Guo CL, Yu D, Zhu J, Gong LL, Li GR, Lv YL, Liu H, An GY, Liu LH.Associations between UGT1A1*6 or UGT1A1*6/*28 polymorphisms and irinotecan-induced neutropenia in Asian cancer patients.Cancer Chemother Pharmacol. 2014 Apr;73(4):779-88. doi: 10.1007/s00280-014-2405-0. Epub 2014 Feb 12.

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    2017-12-27 徐明明

    分析的很详细

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=272951, encodeId=7a832e2951dd, content=分析的很详细, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTL0kmvNe04l9JicpIHXD9TwW48C6E65damXf4iaUm2yXon16DrBMfhibFzc2DZRGYaNA8W7JygDzjr3A/0, createdBy=de1b2233373, createdName=徐明明, createdTime=Wed Dec 27 16:14:27 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029279, encodeId=d62320292e97c, content=<a href='/topic/show?id=9c52e253016' target=_blank style='color:#2F92EE;'>#相关基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72530, encryptionId=9c52e253016, topicName=相关基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Thu Nov 20 17:57:00 CST 2014, time=2014-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1753067, encodeId=53c01e5306792, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Tue Dec 02 10:57:00 CST 2014, time=2014-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003861, encodeId=0bc4200386104, content=<a href='/topic/show?id=3f43e621302' target=_blank style='color:#2F92EE;'>#粒细胞减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76213, encryptionId=3f43e621302, topicName=粒细胞减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Sat Nov 15 05:57:00 CST 2014, time=2014-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1981842, encodeId=16b2198184267, content=<a href='/topic/show?id=311822199b6' target=_blank style='color:#2F92EE;'>#中性粒细胞减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22199, encryptionId=311822199b6, topicName=中性粒细胞减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Fri Oct 31 01:57:00 CST 2014, time=2014-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296594, encodeId=20b11296594de, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Wed May 07 07:57:00 CST 2014, time=2014-05-07, status=1, ipAttribution=)]
    2014-11-20 小华子

    #相关基因#

    0

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    2014-12-02 hanhaisha2020

    #研究发现#

    0

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    2014-11-15 soongzhihua

    #粒细胞减少#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=272951, encodeId=7a832e2951dd, content=分析的很详细, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTL0kmvNe04l9JicpIHXD9TwW48C6E65damXf4iaUm2yXon16DrBMfhibFzc2DZRGYaNA8W7JygDzjr3A/0, createdBy=de1b2233373, createdName=徐明明, createdTime=Wed Dec 27 16:14:27 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029279, encodeId=d62320292e97c, content=<a href='/topic/show?id=9c52e253016' target=_blank style='color:#2F92EE;'>#相关基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72530, encryptionId=9c52e253016, topicName=相关基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Thu Nov 20 17:57:00 CST 2014, time=2014-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1753067, encodeId=53c01e5306792, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Tue Dec 02 10:57:00 CST 2014, time=2014-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003861, encodeId=0bc4200386104, content=<a href='/topic/show?id=3f43e621302' target=_blank style='color:#2F92EE;'>#粒细胞减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76213, encryptionId=3f43e621302, topicName=粒细胞减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Sat Nov 15 05:57:00 CST 2014, time=2014-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1981842, encodeId=16b2198184267, content=<a href='/topic/show?id=311822199b6' target=_blank style='color:#2F92EE;'>#中性粒细胞减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22199, encryptionId=311822199b6, topicName=中性粒细胞减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Fri Oct 31 01:57:00 CST 2014, time=2014-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296594, encodeId=20b11296594de, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Wed May 07 07:57:00 CST 2014, time=2014-05-07, status=1, ipAttribution=)]
    2014-10-31 yuanming7

    #中性粒细胞减少#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=272951, encodeId=7a832e2951dd, content=分析的很详细, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTL0kmvNe04l9JicpIHXD9TwW48C6E65damXf4iaUm2yXon16DrBMfhibFzc2DZRGYaNA8W7JygDzjr3A/0, createdBy=de1b2233373, createdName=徐明明, createdTime=Wed Dec 27 16:14:27 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029279, encodeId=d62320292e97c, content=<a href='/topic/show?id=9c52e253016' target=_blank style='color:#2F92EE;'>#相关基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72530, encryptionId=9c52e253016, topicName=相关基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Thu Nov 20 17:57:00 CST 2014, time=2014-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1753067, encodeId=53c01e5306792, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Tue Dec 02 10:57:00 CST 2014, time=2014-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003861, encodeId=0bc4200386104, content=<a href='/topic/show?id=3f43e621302' target=_blank style='color:#2F92EE;'>#粒细胞减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76213, encryptionId=3f43e621302, topicName=粒细胞减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Sat Nov 15 05:57:00 CST 2014, time=2014-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1981842, encodeId=16b2198184267, content=<a href='/topic/show?id=311822199b6' target=_blank style='color:#2F92EE;'>#中性粒细胞减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22199, encryptionId=311822199b6, topicName=中性粒细胞减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Fri Oct 31 01:57:00 CST 2014, time=2014-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296594, encodeId=20b11296594de, content=<a href='/topic/show?id=29c82219e47' target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22197, encryptionId=29c82219e47, topicName=中性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Wed May 07 07:57:00 CST 2014, time=2014-05-07, status=1, ipAttribution=)]
    2014-05-07 智智灵药

    #中性粒细胞#

    0

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