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CLIN CHEM LAB MED:双中心比较10个全自动商业降钙素原(PCT)免疫检测结果

2020-02-12 MedSci MedSci原创

本双中心研究旨在验证10种不同商业免疫测定法中降钙素原(PCT)值的可比性。

本双中心研究旨在验证10种不同商业免疫测定法中降钙素原(PCT)值的可比性。

将总共176个常规肝素锂血浆样品分成相同的等分试样,并同时使用10种不同的PCT免疫测定法进行分析,包括Kryptor BRAHMS PCT sensitiveAbbott Architect BRAHMS PCTBioMerieux VidasB RAHMSPCTDiasorin联络BRAHMSPCTFujirebioLumipulseGBRAHMSPCTRocheBRAHMSPCT(关于CobasE801),DiazymePCT(关于Roche CobasC702)和SNI MaglumiPCT。。

在多次比较中总是发现高度显着的相关性,相关系数介于0.9180.997之间(所有p <0.001)。 BlandAltman的图分析显示免疫测定之间存在高度可变的偏差,介于±0.2%和±38.6%之间。 Roche Cobas C702SNIBE Maglumi PCT上的Diazyme PCT显示出较大的高估,而Cobas BRAHAMS PCT低估了PCT值。 一致性始终> 80%(所有p <0.001),但是在多个比较中差异很大,在0.1μg/ L时为90–99%,在0.25μg/ L时为81%–99%,在83–100 分别为0.5μg/ L2.0μg/ L94–100%和10μg/ L90–99%。与Diazyme PCTMaglumi PCT与其他方法相比,观察到更大的分歧。

本研究揭示,尽管发现10种商业PCT免疫检测之间存在可接受的相关性,但临床决策阈值的有限一致性仍然是一个主要问题,尤其是在PCT浓度较低的情况下,因此可能会对这一生物标志物的临床价值造成影响。

原始出处:

Giuseppe Lippi,Gian Luca Salvagno,Two-center comparison of 10 fully-automated commercial procalcitonin (PCT) immunoassays

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


 

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    2020-06-10 lvliquan
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