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JACC Heart Failure:增加体力活动可降低绝经女性心力衰竭风险

2018-09-14 国际循环编辑部 国际循环

既往有关体力活动与心力衰竭(HF)风险的相关性研究结果并不一致。一项有关妇女健康倡议(WHI)的最新分析显示,体力活动(包括步行)与绝经后女性HF发生率呈明显负相关关系。

既往有关体力活动与心力衰竭(HF)风险的相关性研究结果并不一致。一项有关妇女健康倡议(WHI)的最新分析显示,体力活动(包括步行)与绝经后女性HF发生率呈明显负相关关系。

研究者布法罗大学的Michael LaMonte等对WHI中137 303例50~79岁受试者自我报告的体力活动及HF发病情况进行分析。中位随访14年,共计2523例女性罹患HF,其中射血分数保留的心力衰竭(HFpEF)及射血分数减低的心力衰竭(HFrEF)者分别为734例和451例。校正社会人口因素、吸烟及饮酒情况、激素治疗及子宫切除情况后,分析发现,总体力活动水平与总体HF、HFpEF及HFrEF均具有明显负相关关系,HR值分别为0.89(趋势P值<0.001)、0.93(趋势P值<0.001)和0.81(趋势P值=0.01)。进一步校正糖尿病高血压、收缩压及舒张压、BMI及心房颤动后,上述负相关关系仍存在。将体力活动作为连续变量进行分析可见,基线总体力活动水平每增加1-log 每周每小时代谢当量,总体HF、HFpEF及HFrEF的发病风险可分别降低9%、8%和10%。需强调,指南推荐的每周150分钟的中等体力活动即可为患者带来HF保护方面的获益。

该研究首次提示,目前,指南推荐水平的体力活动对总体及两个亚型的心力衰竭具有保护作用。宾夕法尼亚大学帕尔曼医学院的Mariell Jessup评论指出,75~84岁白种人女性HF的发病率可达65~74岁者的3倍,且HF的发病率、危险因素流行情况及死亡率在各种族人群中也并不一致。预计至2030年,将有超过800万成人罹患HF。未来,有必要了解HFpEF及HFrEF在人口统计学等方面的差异,从而制定和实施有针对性的人群干预措施。

原始出处:
Michael J. LaMonte, JoAnn E. Manson, et al. Physical Activity and Incidence of Heart Failure in Postmenopausal Women. JACC: Heart Failure. Sep 2018.

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    2019-08-03 hbwxf
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    2019-04-17 amy0550
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objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Sun Sep 16 05:48:08 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345081, encodeId=0b643450815d, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sat Sep 15 10:09:26 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345058, encodeId=38b6345058b7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Sep 15 08:17:17 CST 2018, time=2018-09-15, status=1, ipAttribution=)]
  5. 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likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sun Sep 16 13:10:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570408, encodeId=00f215e040810, content=<a href='/topic/show?id=22c8e88988e' target=_blank style='color:#2F92EE;'>#绝经女性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78898, encryptionId=22c8e88988e, topicName=绝经女性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=790215641232, createdName=zhucaizhong7771, createdTime=Sun Sep 16 13:10:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345172, encodeId=23323451e2c2, content=嗯嗯,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Sun Sep 16 05:48:08 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345081, encodeId=0b643450815d, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sat Sep 15 10:09:26 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345058, encodeId=38b6345058b7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Sep 15 08:17:17 CST 2018, time=2018-09-15, status=1, ipAttribution=)]
    2018-09-16 zhaojie88
  6. 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objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Sun Sep 16 05:48:08 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345081, encodeId=0b643450815d, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sat Sep 15 10:09:26 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345058, encodeId=38b6345058b7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Sep 15 08:17:17 CST 2018, time=2018-09-15, status=1, ipAttribution=)]
    2018-09-16 slcumt
  7. 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  8. 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objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Sun Sep 16 05:48:08 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345081, encodeId=0b643450815d, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sat Sep 15 10:09:26 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345058, encodeId=38b6345058b7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Sep 15 08:17:17 CST 2018, time=2018-09-15, status=1, ipAttribution=)]
    2018-09-16 liumin1987

    嗯嗯,学习了。

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Sun Sep 16 05:48:08 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345081, encodeId=0b643450815d, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sat Sep 15 10:09:26 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345058, encodeId=38b6345058b7, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Sep 15 08:17:17 CST 2018, time=2018-09-15, status=1, ipAttribution=)]
    2018-09-15 smartxiuxiu

    有用

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Sep 15 08:17:17 CST 2018, time=2018-09-15, status=1, ipAttribution=)]
    2018-09-15 龙胆草

    学习谢谢分享

    0

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