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J Endod：牙髓干细胞：使用支架材料在神经移植术和血管发生中的潜力

2017-08-11 MedSci MedSci原创

DPSCs神经移植血管发生
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牙髓是一种高度血管化并受神经支配的组织，它包含不同种类的具有多向分化潜能的干细胞群。现阶段牙髓治疗的焦点集中于病理损伤后的髓组织保存以及牙髓再生。目前，学者们主要通过对人牙髓干细胞(hDPSCs)的研究来探索牙髓再生以及表现为神经元和Schwann细胞再生能力受限的末梢神经损伤的干细胞疗法。

牙髓是一种高度血管化并受神经支配的组织，它包含不同种类的具有多向分化潜能的干细胞群。现阶段牙髓治疗的焦点集中于病理损伤后的髓组织保存以及牙髓再生。目前，学者们主要通过对人牙髓干细胞(hDPSCs)的研究来探索牙髓再生以及表现为神经元和Schwann细胞再生能力受限的末梢神经损伤的干细胞疗法。在此项研究中，研究者发开了一种促使hDPSCs向神经元分化的方法，它需要在神经元成熟前形成神经球。研究团队通过hDPSCs向Schwann细胞分化的实验发现，分化了的hDPSCs具有生成髓鞘以及引导背根神经节形成神经突的能力。另外，除了动态分化能力，hDPSCs对神经和内皮细胞还展现出一种旁分泌作用。对hDPSCs的条件培养基分析显示，其分泌的广谱生长因子包括：脑源性神经营养因子、神经生长因子、血管内皮生长因子和胶质细胞衍生神经营养因子。应用此种条件培养基培养内皮细胞，可以促进细胞迁移和血管发生，表明存在一种旁分泌的促血管生成作用。当存在hDPSCs时，绒毛尿囊膜测定显示血管形成增强，进一步加强了对这种说法的确定性。另外，将包含肽水凝胶和hDPSCs的3维打印羟基磷灰石支架植入免疫抑制的小鼠体内，结

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    2018-05-11 jxrzshh

    #牙髓#

    0

  2. 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    2017-10-05 tidiq

    #支架材料#

    0

  3. 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    2017-12-04 柳叶一刀

    #血管发生#

    0

  4. 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createdBy=ce4f38811844, createdName=tidiq, createdTime=Thu Oct 05 04:23:00 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1976522, encodeId=2d6519e65229e, content=<a href='/topic/show?id=ea788958863' target=_blank style='color:#2F92EE;'>#血管发生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89588, encryptionId=ea788958863, topicName=血管发生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Dec 04 08:23:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998921, encodeId=99da1998921fd, content=<a href='/topic/show?id=8e2ee5200ee' target=_blank style='color:#2F92EE;'>#移植术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75200, encryptionId=8e2ee5200ee, topicName=移植术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Fri Nov 10 11:23:00 CST 2017, time=2017-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233027, encodeId=06e323302ef9, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Sun Aug 13 05:55:48 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544879, encodeId=025815448e969, content=<a href='/topic/show?id=f5576e67147' target=_blank style='color:#2F92EE;'>#牙髓干细胞#</a>, beContent=null, objectType=article, channel=null, 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    2017-11-10 cy0324

    #移植术#

    0

  5. 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    2017-08-13 狼毒花1982

    学习了感谢分享

    0

  6. 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encryptionId=8e2ee5200ee, topicName=移植术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Fri Nov 10 11:23:00 CST 2017, time=2017-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233027, encodeId=06e323302ef9, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Sun Aug 13 05:55:48 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544879, encodeId=025815448e969, content=<a href='/topic/show?id=f5576e67147' target=_blank style='color:#2F92EE;'>#牙髓干细胞#</a>, beContent=null, objectType=article, channel=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo61WAV0ROeLAoicPxPKoKaogwLWLL8STv86qplbdOibN2YR4KxkJicqNectCXGR8gPJhGLc7yYLSdnpx4kaVXndTfu/0, createdBy=a6962042337, createdName=1391e9f2a7m, createdTime=Sat Aug 12 07:01:11 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232408, encodeId=4f202324086a, content=学习，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Fri Aug 11 08:40:06 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232379, encodeId=594c2323e982, content=不错的，学习了，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Fri Aug 11 07:55:25 CST 2017, time=2017-08-11, status=1, ipAttribution=)]
    2017-08-12 ms6519009802973839

    #牙髓干细胞#

    0

  7. 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encryptionId=8e2ee5200ee, topicName=移植术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Fri Nov 10 11:23:00 CST 2017, time=2017-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233027, encodeId=06e323302ef9, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuNreCBwuEU9I5ich0uE1zdHnicdKjEibG64cgLHSp5sMMFMiatLiaDaSrGOj1jAaDuTZo7vDLDhgRFHt6/0, createdBy=caa52003923, createdName=狼毒花1982, createdTime=Sun Aug 13 05:55:48 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544879, encodeId=025815448e969, content=<a href='/topic/show?id=f5576e67147' target=_blank style='color:#2F92EE;'>#牙髓干细胞#</a>, beContent=null, objectType=article, channel=null, 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    2017-08-12 狼毒花1982

    学习了感谢分享

    0

  8. 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    2017-08-12 1391e9f2a7m

    非常好的内容呢，认真学习

    0

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    2017-08-11 执着追梦

    学习，谢谢分享

    0

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beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo61WAV0ROeLAoicPxPKoKaogwLWLL8STv86qplbdOibN2YR4KxkJicqNectCXGR8gPJhGLc7yYLSdnpx4kaVXndTfu/0, createdBy=a6962042337, createdName=1391e9f2a7m, createdTime=Sat Aug 12 07:01:11 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232408, encodeId=4f202324086a, content=学习，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Fri Aug 11 08:40:06 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232379, encodeId=594c2323e982, content=不错的，学习了，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Fri Aug 11 07:55:25 CST 2017, time=2017-08-11, status=1, ipAttribution=)]
    2017-08-11 中医痴

    不错的，学习了，谢谢分享！

    0

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