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Am J Clin Dermatol:不同激光手段治疗非黑素瘤皮肤癌的疗效

2021-09-14 MedSci原创 MedSci原创

手术是治疗非黑色素瘤皮肤癌的主要手段,激光是另一种选择选择。发表于Am J Clin Dermatol的一项回顾性研究对激光治疗非黑色素瘤皮肤癌进行了系统回顾和荟萃分析,以探究激光治疗非黑色素瘤皮肤癌

手术是治疗非黑色素瘤皮肤癌的主要手段,激光是另一种选择选择。发表于Am J Clin Dermatol的一项回顾性研究对激光治疗非黑色素瘤皮肤癌进行了系统回顾和荟萃分析,以探究激光治疗非黑色素瘤皮肤癌的疗效和安全性。

该综述供纳入了32项研究(6项随机对照试验和26项队列研究):27项评估了基底细胞癌(BCCs),3项评估了鳞状细胞癌,2项评估了两者,共计4755例BCCs和214例鳞状细胞癌。大多数BCC是低风险的。

结果显示,在平均7.9年的随访期间,Nd:YAG激光(7项研究,3286个BCC)的RR为3.1%(95%置信区间[CI]1.4-6.4%),瘢痕和色素沉着的比率很低(<20%)。在平均2.1年的随访期间,二氧化碳激光(10项研究,904个BCCs)的RR为9.4%(95% CI 4.1-20),副作用率低。脉冲染料激光(8项研究,206个BCCs)的RR为38%(95%CI为24-55)。在两项研究中,Nd:YAG激光对鲍温病的RR为10%(95% CI 2-31),而在三项研究中,CO2激光对鳞状细胞癌的RR为22%(95% CI 5-61)。

综上所述,基于队列研究,Nd:YAG激光是治疗低风险BCC的一种安全和有效的方式。根据文献中先前研究应用的设置,二氧化碳激光器的疗效不如Nd:YAG激光器,因此不能推荐用于BCC治疗。由于数据不足,无法就激光治疗鳞状细胞癌的疗效得出结论。

原始出处:

Eran Sharon, et al., Laser Treatment for Non-Melanoma Skin Cancer: A Systematic Review and Meta-Analysis. Am J Clin Dermatol. 2021 Jan;22(1):25-38. doi: 10.1007/s40257-020-00562-8.

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    2021-09-16 oliver169
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    2021-09-15 ms4000001729026290

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